A0AA35RAB0 · A0AA35RAB0_GEOBA

Function

function

Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Lipid metabolism.
Phospholipid metabolism; phosphatidylcholine biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site116-118S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site198-199S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial membrane
Molecular Functionphosphatidyl-N-dimethylethanolamine N-methyltransferase activity
Molecular Functionphosphatidyl-N-methylethanolamine N-methyltransferase activity
Molecular Functionphosphatidylethanolamine N-methyltransferase activity
Biological Processmethylation
Biological Processphosphatidylcholine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylethanolamine N-methyltransferase
  • EC number
  • Short names
    PEAMT
    ; PEMT
  • Alternative names
    • Phospholipid methyltransferase
      (PLMT
      )

Gene names

    • ORF names
      GBAR_LOCUS5362

Organism names

Accessions

  • Primary accession
    A0AA35RAB0

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-26Lumenal
Transmembrane27-49Helical
Topological domain51-62Lumenal
Transmembrane70-92Helical
Transmembrane104-123Helical
Transmembrane130-153Helical
Topological domain133-175Lumenal
Transmembrane165-194Helical
Topological domain197-214Cytoplasmic

Keywords

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    214
  • Mass (Da)
    23,535
  • Last updated
    2024-01-24 v1
  • Checksum
    290ADE69296398AB
MDGGPQDNTRVRRLEEMASALELLNELASPSVLLACPLVMLNPLIWNLIVRHEYNTRSVSRLCGGPRAGVVLVACIVMVNNSIRTSFFHYIVGKNSKLQFLEDNVGATIAGYVIIGVGVLLVLSSTWRLGFFCTFLGDYFGILLDARVTGFPFNILNHPMFWGSFLIYVGDSVLCASAVAFLLSLFIGLSYVLAAAFEVPFTAKIYAQKETKKI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CASHTH010000799
EMBL· GenBank· DDBJ
CAI8007760.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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