A0A9Y4KCF8 · A0A9Y4KCF8_9TELE

Function

Catalytic activity

  • (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
    This reaction proceeds in the backward direction.
  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+
    This reaction proceeds in the forward direction.
  • 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+
    This reaction proceeds in the forward direction.
  • 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • 2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+
    This reaction proceeds in the forward direction.
  • Hydrolyzes glycerol monoesters of long-chain fatty acids.
    EC:3.1.1.23 (UniProtKB | ENZYME | Rhea)
  • a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a monoacylglycerol + H2O = a fatty acid + glycerol + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    EC:3.1.1.79 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H+ + hexadecanoate
    This reaction proceeds in the forward direction.
  • cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H+
    This reaction proceeds in the forward direction.

Pathway

Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site438

GO annotations

AspectTerm
Cellular Componentcaveola
Cellular Componentcytosol
Cellular Componentlipid droplet
Molecular Functionlipase activity
Biological Processcholesterol metabolic process
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hormone-sensitive lipase
  • EC number
  • Alternative names
    • Monoacylglycerol lipase LIPE
    • Retinyl ester hydrolase

Gene names

    • Name
      lipe

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Pomacentridae > Stegastes

Accessions

  • Primary accession
    A0A9Y4KCF8

Proteomes

Subcellular Location

Cell membrane
Cytoplasm, cytosol
Lipid droplet
Membrane, caveola

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain16-327Hormone-sensitive lipase N-terminal
Domain360-512Alpha/beta hydrolase fold-3
Region640-660Disordered
Domain688-751Alpha/beta hydrolase fold-3
Region776-812Disordered
Compositional bias779-795Basic and acidic residues

Sequence similarities

Belongs to the 'GDXG' lipolytic enzyme family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    846
  • Mass (Da)
    91,546
  • Last updated
    2024-01-24 v1
  • Checksum
    4860500A0BFF1F53
MDRALNSDTVMDTKAVFAALYSVCEENAAFFSGGAKGSQGDAARRLVEAVNVIQEHARSLEPVITGFAAVYHHFDFDPHIPANGYRSLVKVVRCCLLHIIHKGRYITANRRSIFFRVAHNAGEMEAYCNALCQLRALLYLAQRMLHDNSHGNLFFQDESGLSESFVREYASMHKGCFYGRCLGFQFTPAIRPCLQTIAIGLVAFGENYKRHQSGIGVAASSLFNSGKYAIDPELRGAEFDRITQNLDVHFWKTFWNITETEVLSGLASMTSTQVKVNRALSVPSVPFDLPLAANHRASVTISPPSAHIGTAPVQMRLISYDLREGQDSETLLSLSRSEGGAISLSLGLKTKRLPSSPCLLIHFHGGGFVAQTSKSHEPYLKSWSQDLGVPILSVDYSLAPEAPFPRALEECFYAYCWALRNHHLLGWTGEKVCLAGDSAGGNLCVTTSMRAAAFGVRMPDGIVAAYPATLLTAYASPSRLLTLMDPLLPLTVLSRCLSAYAGSEPQTEKQVAKVSTLSLVRRDTALMLRDFRQGASNWIQSLLDPNRASASPSTNAELPGATDAVRKSISEASICSPHADPPVPTEPSELLSRKLSVKSQTCQDLGSHNNSVPYSAPLLSERTPEDVSFFLTKDGDTSISSDLSSVAIPPPPAGEDGSELEHRREYPLGFEPLRSEQLAEIRVESSPVVKDPFCSPLLAPDSMLKGLPPIHIVACALDPMLDDSVMFAKRLRNIDQPVTLCVVDDLPHGFLSLSQLSKETREAANVCAERIRAVFTQDTPPEPRKHRKLERTDRGVSAPSGDSGPLFVGPTEGGELAVGRGAKIADGEGSVAVAAQNNTDAGGIGA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3B4Z9V3A0A3B4Z9V3_9TELElipe867

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias779-795Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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