A0A9Y4KCF8 · A0A9Y4KCF8_9TELE
- ProteinHormone-sensitive lipase
- Genelipe
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids846 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2OThis reaction proceeds in the backward direction.
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+This reaction proceeds in the forward direction.
- 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H+This reaction proceeds in the forward direction.
- 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+This reaction proceeds in the forward direction.
- 2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H+This reaction proceeds in the forward direction.
- all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H+ + hexadecanoateThis reaction proceeds in the forward direction.
- cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H+This reaction proceeds in the forward direction.
Pathway
Glycerolipid metabolism; triacylglycerol degradation.
Lipid metabolism.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 438 | |||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | caveola | |
Cellular Component | cytosol | |
Cellular Component | lipid droplet | |
Molecular Function | lipase activity | |
Biological Process | cholesterol metabolic process | |
Biological Process | lipid catabolic process |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHormone-sensitive lipase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Pomacentridae > Stegastes
Accessions
- Primary accessionA0A9Y4KCF8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 16-327 | Hormone-sensitive lipase N-terminal | ||||
Sequence: VFAALYSVCEENAAFFSGGAKGSQGDAARRLVEAVNVIQEHARSLEPVITGFAAVYHHFDFDPHIPANGYRSLVKVVRCCLLHIIHKGRYITANRRSIFFRVAHNAGEMEAYCNALCQLRALLYLAQRMLHDNSHGNLFFQDESGLSESFVREYASMHKGCFYGRCLGFQFTPAIRPCLQTIAIGLVAFGENYKRHQSGIGVAASSLFNSGKYAIDPELRGAEFDRITQNLDVHFWKTFWNITETEVLSGLASMTSTQVKVNRALSVPSVPFDLPLAANHRASVTISPPSAHIGTAPVQMRLISYDLREGQD | ||||||
Domain | 360-512 | Alpha/beta hydrolase fold-3 | ||||
Sequence: LIHFHGGGFVAQTSKSHEPYLKSWSQDLGVPILSVDYSLAPEAPFPRALEECFYAYCWALRNHHLLGWTGEKVCLAGDSAGGNLCVTTSMRAAAFGVRMPDGIVAAYPATLLTAYASPSRLLTLMDPLLPLTVLSRCLSAYAGSEPQTEKQVA | ||||||
Region | 640-660 | Disordered | ||||
Sequence: SSDLSSVAIPPPPAGEDGSEL | ||||||
Domain | 688-751 | Alpha/beta hydrolase fold-3 | ||||
Sequence: VVKDPFCSPLLAPDSMLKGLPPIHIVACALDPMLDDSVMFAKRLRNIDQPVTLCVVDDLPHGFL | ||||||
Region | 776-812 | Disordered | ||||
Sequence: TQDTPPEPRKHRKLERTDRGVSAPSGDSGPLFVGPTE | ||||||
Compositional bias | 779-795 | Basic and acidic residues | ||||
Sequence: TPPEPRKHRKLERTDRG |
Sequence similarities
Belongs to the 'GDXG' lipolytic enzyme family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length846
- Mass (Da)91,546
- Last updated2024-01-24 v1
- Checksum4860500A0BFF1F53
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3B4Z9V3 | A0A3B4Z9V3_9TELE | lipe | 867 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 779-795 | Basic and acidic residues | ||||
Sequence: TPPEPRKHRKLERTDRG |
Keywords
- Technical term