A0A9Y1HPJ5 · A0A9Y1HPJ5_9FLAV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3870 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Acts as a cofactor for the NS3 protease activity.
Packages viral RNA to form a viral nucleocapsid and thereby protects viral RNA. Also plays a role in transcription regulation. Protects the incoming virus against IFN-induced effectors.
Plays a role in the regulation of viral RNA replication.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 47 | For N-terminal protease activity | ||||
Sequence: H | ||||||
Active site | 67 | For N-terminal protease activity | ||||
Sequence: C | ||||||
Site | 163-164 | Cleavage; by autolysis | ||||
Sequence: CS | ||||||
Active site | 1638 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: H | ||||||
Active site | 1675 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: D | ||||||
Active site | 1732 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: S |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Pestivirus
Accessions
- Primary accessionA0A9Y1HPJ5
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Peripheral membrane protein
Virion membrane ; Peripheral membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 660-677 | Helical | ||||
Sequence: IHAIIWVLLLSGVNAYSW | ||||||
Transmembrane | 1020-1041 | Helical | ||||
Sequence: YIVIVVVALLGGKISLWILIAF | ||||||
Transmembrane | 1061-1086 | Helical | ||||
Sequence: FMYSSIVVEANLETIAHFLLLLALLY | ||||||
Transmembrane | 1093-1120 | Helical | ||||
Sequence: LFLSVYFVLTSSAKTTIIFIILCLIGFA | ||||||
Transmembrane | 1132-1149 | Helical | ||||
Sequence: FESAYLTMLVIISILVIA | ||||||
Transmembrane | 1154-1172 | Helical | ||||
Sequence: FCFFTITVTVVLFRLAVVL | ||||||
Transmembrane | 1178-1196 | Helical | ||||
Sequence: YIIVYILFVXXXXXXXIYY | ||||||
Transmembrane | 1203-1223 | Helical | ||||
Sequence: LLLLVMSFAFLYGLIGILNAL | ||||||
Transmembrane | 1229-1251 | Helical | ||||
Sequence: VFVNTVIVNWPRIGILMSAYLAL | ||||||
Transmembrane | 1263-1290 | Helical | ||||
Sequence: TGYILGAAAVVLTIISTVIDITILWTII |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-163 | Peptidase C53 | ||||
Sequence: MNFEIFFRVGTTPPRGAKEPVYDRNLQPLFGVKHSQLHPKSTLILPHARGKRTQQVKLVDLPRKGDCERTGGEVSGIFVKPGPIWYSDYEGPVYHRIPLELCAKSTPCNVKKLIGRMEGSDTKLYHVYTCPDGCLFFVRANQSKTTYFMVNNALDAPLWVQSC | ||||||
Domain | 1423-1569 | Peptidase C74 | ||||
Sequence: KRLVIKHKVNNPGVKRWFGAEEIFGMPKIYMVTHIKNLTKDKAILCSVCENNNSSRRCPKCGCKGTPIKCGMTLSEFEERFYTKIFITEYNQNDHRVEGPGKIVRYMDNGLLYLRNLPILATKQKMLIVGNLGNEIADLEHLGWTLR | ||||||
Domain | 1570-1743 | Peptidase S31 | ||||
Sequence: GPAVCKKITHSTKCQATILDKMTAFFGIMPRGATPRAPTRFPTSLLRIRRGFENGWAYTHPGGISSVHHVTEGKDIFVSDDLGRTKVVCQSTNKTSDETEYGIKTDSACAEGTRCYAFNPEATNISGTKGAMVHLRKTGSEFNCVTAMGTPAYFDLKHLKGWSGLPIFEAGSGK | ||||||
Domain | 1782-1940 | Helicase ATP-binding | ||||
Sequence: ISKMQRGEFKQVTLATGAGKTTELPRRVIEEVGRHKRILVLIPLRAAAEGVYRFMKCKYPSISFNLRIGELKEGDMATGITYASYGYFCQMEMPKLKNAITTYNYVFLDEYHCATAEQLAVMSKIHRFSEEVRVVAMTATPAGTVSRTGQKHTIEEVQL | ||||||
Domain | 1958-2123 | Helicase C-terminal | ||||
Sequence: DLKVPTMELKNNCLVFVPTRKLAAENAKNLASKGYNAGYFFSGEDPTAIRNITAKSPYIVVATNAIESGVTLPDLDTVIDTGLKYEKRLRINEKMPYIVTGLKRMAVTIGEQAQRKGRVGRVKPGRYLKGPTTASGEKDYHYDLLQAQMYGVQDGINITKSFREMN | ||||||
Domain | 3496-3619 | RdRp catalytic | ||||
Sequence: PVAVSFDTKAWDTQVTPKDLLLISEVQKYYFKKKWHKFIDTITKHMLEVPVVTEDGQVYFRVGQRGSGQPDTSAGNSMLNVLTMIYCFCTANNIPYSAFSKVAKIHVCGDDGFLITERALGEKF |
Sequence similarities
Belongs to the pestivirus polyprotein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,870
- Mass (Da)436,709
- Last updated2023-11-08 v1
- Checksum0FCDEB6D65268BAD