A0A9X9PGR7 · A0A9X9PGR7_ADEBA

Function

function

Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site170-177ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nucleolus
Cellular Componenthost cell nucleoplasm
Cellular Componentvirion component
Molecular FunctionATP binding
Molecular FunctionDNA binding
Biological ProcessDNA-templated transcription
Biological Processnuclear capsid assembly
Biological Processregulation of DNA-templated transcription
Biological Processviral DNA genome packaging via site-specific sequence recognition
Biological Processviral release from host cell
Biological Processviral transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Packaging protein 1
  • Alternative names
    • Packaging protein IVa2

Gene names

    • Name
      IVa2

Organism names

Accessions

  • Primary accession
    A0A9X9PGR7

Proteomes

Subcellular Location

Virion
Host nucleus, host nucleoplasm
Host nucleus, host nucleolus
Note: Located at a unique vertex of the capsid. Present in about 6-8 copies per virion.

Keywords

PTM/Processing

Keywords

Expression

Induction

Expressed in the intermediate phase of the viral replicative cycle.

Interaction

Subunit

Homodimer. Part of a genome packaging complex composed of packaging proteins 1, 2 and 3; this complex specifically binds to the packaging sequence on the left end of viral genomic DNA and performs packaging of the viral genome. Interacts with protein 33K.

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-29Basic and acidic residues
Region1-36Disordered
Region439-448DNA-binding

Sequence similarities

Belongs to the adenoviridae packaging protein 1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    448
  • Mass (Da)
    51,508
  • Last updated
    2023-11-08 v1
  • Checksum
    3A99126988771597
METKARKRKISNIENHLETHTEHDASSSPPIFDHGDNAHTDVTSLERQNVTRFGSKQTCPVLQQQSESEKYRDLLDGTAVEHLHKLWDKLNPLLQVLQNMTYAEGLKPLKLYDSIDELLSMGGSTLLQTLQHDYLNILTTEKSVYPFLNSDGTCKSLNYDMQPLIGIIYGPTGCGKSQLLRNLMSSKAIRPTPETVFFITPQIDMMPPQEILAWESQICEGNYEAGPQNTFIPQSGCIKPEFIQLNYEELLKEHNHNVAHPNNIFAHAAKKGPIAIIMDECMEELGGHKSIAKFFHAFPSKLHDKFPQCTGYTLLVVLHNMNPRKDLAGNISTLKIQAKMHIISPKMHPSQLSRFINTYTKSLPLPICLLLKDIFNFHATHCKYDWIIYNCNPLHEALQWIYMNPVEGLMPMYLNVQTLLYTVLQKIHKTKQDRERWTRYYQNKKLKH

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-29Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ON217544
EMBL· GenBank· DDBJ
UZF96917.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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