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A0A9X9I063 · A0A9X9I063_NEISU

  • Protein
    Peptidoglycan D,D-transpeptidase MrdA
  • Gene
    mrdA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes cross-linking of the peptidoglycan cell wall.

Catalytic activity

  • Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
    EC:3.4.16.4 (UniProtKB | ENZYME | Rhea)

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

168250100150200250300350400450500550600650
TypeIDPosition(s)Description
Active site341Acyl-ester intermediate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan L,D-transpeptidase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peptidoglycan D,D-transpeptidase MrdA
  • EC number
  • Alternative names
    • Penicillin-binding protein 2
      (PBP-2
      )

Gene names

    • Name
      mrdA
    • ORF names
      KCG56_05515

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TT0073
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria

Accessions

  • Primary accession
    A0A9X9I063

Proteomes

Subcellular Location

Cell inner membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane27-51Helical

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain74-250Penicillin-binding protein dimerisation
Domain282-625Penicillin-binding protein transpeptidase
Region641-682Disordered
Compositional bias653-676Polar residues

Sequence similarities

Belongs to the transpeptidase family. MrdA subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    682
  • Mass (Da)
    76,070
  • Last updated
    2023-11-08 v1
  • MD5 Checksum
    67A54726DE5F4FAFA4EFA9274A25788C
MKPILPRRLSGGQHTKKPSAQAAQADALLRLLVAFILIVIFFSILLARFFYLQVTQHNEFSGQASSNRITLIPTPPVRGEIVDINGVPLAKNYPVFSLEVIPSRIEGKMEDVIEALKKYVDITPTDLKRFKKYRESYRKFENIPLKLRLTDEEAARLSVHLREFKGVEVNSRTFREYPYGKLTSHFLGYIGRISDKDKEMLEEEGLTALYRGSTHIGKSGLEKYYEHQLHGVPGYQEVEKDAYGNIVRVLKNVPSQMGQTLRLGMDIRMQQEADRILGDRRGGLVAINPQDGTVLAFVSKPSFDPNLFIDGIDSDTWKMLNDDWKKPLINRVTQGLYPPGSTFKPFMGMALLESGKITQNTIVPAPGAWSIPGSRHIFRDSVRSGHGSANLSKAIQVSSDTFFYRLGYEMGIDKAAPYLAQFGFGQKTGIDLPSEYAGVLPSREWKAKRFAKSSDPTAKEWRAGEMVSVSIGQGYNAYTPLQMAHATASLANDGVVHQPHLVKEILNFGARKITRINPNPERQIPFKADNFEYVKRAMEKVLKPGGTAHRIGGGLSYTMGGKTGTAQVVQIKQGGRYNAAALREQHRDHAWFISFAPLEKPEIAIAVILENGGWGAYAAPLAREMTDFYMLHVKPQQFSDGLESDSAKTETTDKHQPITSIFQSAYGLTPTSPASQPEVHHE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias653-676Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP073116
EMBL· GenBank· DDBJ
UTG72852.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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