Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A9X9HXT2 · A0A9X9HXT2_NEISU

  • Protein
    DNA topoisomerase 4 subunit A
  • Gene
    parC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Features

Showing features for site, active site.

1767100200300400500600700
Type
IDPosition(s)Description
Site49Interaction with DNA
Site85Interaction with DNA
Site87Interaction with DNA
Site128Transition state stabilizer
Active site129O-(5'-phospho-DNA)-tyrosine intermediate

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentcytoplasm
Cellular ComponentDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
Cellular Componentextrinsic component of plasma membrane
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Biological Processchromosome segregation
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 4 subunit A
  • EC number
  • Alternative names
    • Topoisomerase IV subunit A

Gene names

    • Name
      parC
    • ORF names
      KCG56_11420

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TT0073
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria

Accessions

  • Primary accession
    A0A9X9HXT2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterotetramer composed of ParC and ParE.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-490DNA topoisomerase type IIA

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    767
  • Mass (Da)
    84,483
  • Last updated
    2023-11-08 v1
  • MD5 Checksum
    4679874EF0CB22FBDAD498CC8D6219D9
MTEHISAPSPSPVGEDYLLLGQYAERAYLEYAMSVVKGRALPEVSDGQKPVQRRILFAMRDMGLTAGAKPVKSARVVGEILGKYHPHGDSSAYEAMVRMAQDFTLRYPLIDGIGNFGSRDGDGAAAMRYTEARLTPIAELLLSEINQGTVDFVPNYDGAFDEPVHLPARLPMVLLNGASGIAVGMATEIPSHNLNEVTQAAIALLKKPTLETADLMQYIPAPDFAGGGQIITPADELRRIYETGKGSVRVRARYEIEKLARGQWRVIVTELPPNANSAKILAEIEEQTNPKPKAGKKQLNQDQLNTKKLMLDLIDRVRDESDGEHPVRLVFEPKSSRIDTDTFINTLMAQTSLEGNVSMNLVMMGLDNRPAQKNLKTILHEWLDFRVVTVTRRLKFRLNQVEKRLHILEGRLKVFLHIDEVIKVIRESDNPKADLMAAFGLTEIQAEDILEIRLRQLARLEGFKLEKELNELSEEQGRLNILLGDENEKRKLIIKEMQADMKQFGDARRTLVEEAGRAVLTQTTADEPITLILSEKGWIRSRAGHNLDLSQTAFKEGDRLKQTLEGRTVLPVVILDSLGRTYTLDAAEIPGGRGDGVPVSSLIELQNGAKPVAMLTGQPEQHYLLSGSGGYGFITKLADMVGRVKAGKVVMTVDSGETVLPPVAVYASSLINPDCKVVLASSDHRLLAFSIGELKVMPKGRGLQLMSLAEGASLEHIMVTTSPEFTVVSVGRRGAEHQEKLRIADIDGKRGKKGKVLEISGRLKSLS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP073116
EMBL· GenBank· DDBJ
UTG71909.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help