A0A9X9HXT2 · A0A9X9HXT2_NEISU
- ProteinDNA topoisomerase 4 subunit A
- GeneparC
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids767 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 49 | Interaction with DNA | |||
Site | 85 | Interaction with DNA | |||
Site | 87 | Interaction with DNA | |||
Site | 128 | Transition state stabilizer | |||
Active site | 129 | O-(5'-phospho-DNA)-tyrosine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | cytoplasm | |
Cellular Component | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex | |
Cellular Component | extrinsic component of plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Biological Process | chromosome segregation | |
Biological Process | DNA topological change |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 4 subunit A
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria
Accessions
- Primary accessionA0A9X9HXT2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Heterotetramer composed of ParC and ParE.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length767
- Mass (Da)84,483
- Last updated2023-11-08 v1
- MD5 Checksum4679874EF0CB22FBDAD498CC8D6219D9
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP073116 EMBL· GenBank· DDBJ | UTG71909.1 EMBL· GenBank· DDBJ | Genomic DNA |