A0A9X9HVP9 · A0A9X9HVP9_NEISU

  • Protein
    Sulfite reductase [NADPH] flavoprotein alpha-component
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    2/5

Function

function

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site64-69FMN (UniProtKB | ChEBI)
Binding site111-114FMN (UniProtKB | ChEBI)
Binding site147-156FMN (UniProtKB | ChEBI)
Binding site319FAD (UniProtKB | ChEBI)
Binding site353FAD (UniProtKB | ChEBI)
Binding site383-386FAD (UniProtKB | ChEBI)
Binding site401-403FAD (UniProtKB | ChEBI)
Binding site416-419FAD (UniProtKB | ChEBI)
Binding site516-517NADP+ (UniProtKB | ChEBI)
Binding site522-526NADP+ (UniProtKB | ChEBI)
Binding site558NADP+ (UniProtKB | ChEBI)
Binding site596FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular Functionsulfite reductase (NADPH) activity
Biological Processcysteine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sulfite reductase [NADPH] flavoprotein alpha-component
  • EC number
  • Short names
    SiR-FP

Gene names

    • ORF names
      KCG54_04220

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TT0077
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria

Accessions

  • Primary accession
    A0A9X9HVP9

Proteomes

Subcellular Location

Interaction

Subunit

Alpha8-beta8. The alpha component is a flavoprotein, the beta component is a hemoprotein.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain58-196Flavodoxin-like
Domain230-445FAD-binding FR-type

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    596
  • Mass (Da)
    65,029
  • Last updated
    2023-11-08 v1
  • Checksum
    559CF7B49E76047A
MSQANPLPPELSVQLSALSPTQLAWLSGYCWAQSQGVSGVAAEPSALQTAASTVSRRVLVLSASQTGNARSVAESLHAKLQAAGVEARLSSASDFKSKTLPDGDIVLLVTSTQGEGEPPEEALPLYKFIYGKKKPDLSKLTFAVLGLGDSSYPNFCQAGKDFDAKFAELGAGRLNDLGICDLEFQTDADAWIAAVVPKVAELTAQAASPSISTAPNGSATPSNDAVYTKEKPYTAILSVRQKITSRDAEKDVEHIEIDLSGSGLHYQAGDALGVWPLNAGDLVQEILDLNQLSGNETVQLSDGRETDIRTALTESADITQNTPAFVQQYAELTNNEELKTIAADKAQLDAYLAATPPVGVFAAHLHPLDAQTLYSLFRPQTPRLYSIASAQDEVGEEVHLTVGVVRFNHHDHTYTGVASGYLGERLEEGSEIRVFVEPNPNFRLPQNGDTPIIMIGAGTGVAPFRSFMQQRAANGDSGKNWLFFGNQRLADDFLYQLEWSDWRKDGLLTRADLAWSRQGEHKVYVQHKITERAAEVWNWLQQGAHIYVCGDAARMARDVENALIEVIETQGKLSRDEAEDYLNDLREDKRYQRDVY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP073115
EMBL· GenBank· DDBJ
UTG70522.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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