A0A9X8CY47 · A0A9X8CY47_9BURK
- ProteinDNA polymerase III subunit epsilon
- GenednaQ
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids200 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
Cofactor
Protein has several cofactor binding sites:
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | DNA-directed DNA polymerase activity | |
Molecular Function | exonuclease activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA replication |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA polymerase III subunit epsilon
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Acidovorax
Accessions
- Primary accessionA0A9X8CY47
Proteomes
Interaction
Subunit
DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-175 | Exonuclease | ||||
Sequence: RQIVLDTETTGLSAENGDRIIELGCVELLNRKLTGNNLHMYFNAGRDSHEDALRVHGITTEFLKDKPRFEQQVDQILEYLQGAEIIIHNAPFDVGFLNKELQRTGKPPLKSWVEGVIDTLAMAKERYPGKRNSLDSLCDRLGVDNSGRTLHGALLDAELLADVYINLTRGQDA |
Family and domain databases
Sequence
- Sequence statusFragment
- Length200
- Mass (Da)22,211
- Last updated2023-11-08 v1
- ChecksumBD4346604D60DCE8
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 200 | |||||
Sequence: T |