A0A9X7YC06 · A0A9X7YC06_SPHYA

Function

function

Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per monomer. In the dimeric form the Ca2+ is bound by different amino acids with binding of each Ca2+ shared with ligands coming from each monomer. The Ca2+ ion may have a role in catalysis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site243Ca2+ 1 (UniProtKB | ChEBI); in dimeric form
Active site278Proton acceptor
Active site280Nucleophile
Binding site283Ca2+ 1 (UniProtKB | ChEBI); in dimeric form
Binding site288Ca2+ 1 (UniProtKB | ChEBI); in dimeric form
Binding site325Ca2+ 1 (UniProtKB | ChEBI); in dimeric form

GO annotations

AspectTerm
Cellular Componentcell outer membrane
Molecular Functionmetal ion binding
Molecular Functionphospholipase activity
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipase A1
  • EC number
  • Alternative names
    • Phosphatidylcholine 1-acylhydrolase

Gene names

    • ORF names
      H3V42_24390

Organism names

Accessions

  • Primary accession
    A0A9X7YC06

Proteomes

Subcellular Location

Cell outer membrane
; Multi-pass membrane protein
Note: One of the very few enzymes located there.

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-33
ChainPRO_504101275534-415Phospholipase A1

Interaction

Subunit

Homodimer; dimerization is reversible, and the dimeric form is the active one.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region145-168Disordered
Compositional bias146-168Pro residues

Sequence similarities

Belongs to the phospholipase A1 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    415
  • Mass (Da)
    44,762
  • Last updated
    2023-11-08 v1
  • Checksum
    B7707765E61989F4
MIDRLFARACRARVHLLLIAGTALCPTMLRAQAPVETLIGRVGATDAQGMAAIELRFLNMGAAPATMPLPDRVEALVEQDGAARRLWLRRAPGVPETVEIAPGGFAQARYQLAASDMAEGALLSIPAWNSPQVALHGAAPARMAAASPVPVPPPPPPPGTPVPPPVAPPADRSAGNAFIGNLAPYEPIYAVYGPGTNTDARLQLSFEYRLFGSRDAAHLPSSWRDGLHFAYTQRMFWDLGANSMPFRNIDYQPEIIYVTPTRMLKNGMSLALQGGLRHESNGRDGDASRSINSVYVAPMAAFSLGEERRLLVAPRLTFYVGDKSDNPDIVRYRGHAGLFLQVGDDDGLRLSTNSRFNFGSGKGAINADLSYPLPRLLGGGPDLYLFAQGFAGYGENLLDYNRSITRLRIGFALVR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias146-168Pro residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP060122
EMBL· GenBank· DDBJ
QNG44934.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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