A0A9X7UII6 · A0A9X7UII6_SPHYA

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site120Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site121Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site156substrate
Binding site182substrate
Site192-193Cleavage; by autolysis
Active site193Nucleophile
Binding site193substrate
Binding site280substrate
Binding site403substrate
Binding site408substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglutamate N-acetyltransferase activity
Molecular FunctionL-glutamate N-acetyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      H3V42_14615

Organism names

Accessions

  • Primary accession
    A0A9X7UII6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50410277031-192Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5041027704193-408Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    408
  • Mass (Da)
    41,998
  • Last updated
    2023-11-08 v1
  • Checksum
    D74B84152CF523ED
MTDRSPLAPAAFPALPAIAGVTLRVAKARYKNWDRCDLTYVELDAGTAVAGVTTQSKCPSPEVEWCRDAIPMGQARAVVVNAGNANAFTGHRGRAAVEAIAAKVANHLSCQPSDIFVSSTGVIGVPLPIDKAEAGLEAAFVAAPCGWEDAANTIGTTDTYAKGAHVSAMIGDTRVDLVGIIKGSGMIAPDMATMLGYIFTDAAIDPALLQQILSAANKRTFSCITVDSDTSTSDTVLAFATGKAGNAPLVSMDDAGADAFAAALSDLCRQLAHLVVRDGEGASKFIEITVEGAESDASAHRIALSIANSPLVKTAIAGEDANWGRVVMAVGKAGEPAERDKLAIRFGATQVAAGGLALDGYDEAPVAAHLKGQDIVIGVDIGLGEGRATVWTCDLTHGYISINADYRS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP060122
EMBL· GenBank· DDBJ
QNG48637.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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