A0A9X7U7X0 · A0A9X7U7X0_SPHYA

Function

function

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

Catalytic activity

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.

Features

Showing features for binding site, active site.

1140102030405060708090100110120130140
Type
IDPosition(s)Description
Binding site115-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site42-445-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site66-685-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site71-72(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)
Active site74Proton donor
Binding site985-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site112(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentriboflavin synthase complex
Molecular Function6,7-dimethyl-8-ribityllumazine synthase activity
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6,7-dimethyl-8-ribityllumazine synthase
  • EC number
  • Short names
    DMRL synthase
    ; LS
    ; Lumazine synthase

Gene names

    • Name
      ribH
    • ORF names
      H3V42_26945

Organism names

Accessions

  • Primary accession
    A0A9X7U7X0

Proteomes

Subcellular Location

Family & Domains

Sequence similarities

Belongs to the DMRL synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    140
  • Mass (Da)
    14,939
  • Last updated
    2023-11-08 v1
  • Checksum
    9E781B024279746B
MAKFLIVEARFYDHLNDLLIEGAKAALDEAGHKYEVVTVPGALEIPGAIALAAETGRFDGFVAIGVVIRGETYHFEVVSNESARGLMALSMDAIAIGNGILTVENEEQALVRARPDQKDKGGEAAKAAIAMLGLRERFAI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP060122
EMBL· GenBank· DDBJ
QNG45391.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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