A0A9X5I4Q8 · A0A9X5I4Q8_9CYAN

Function

function

Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Bacterial outer membrane biogenesis; LPS core biosynthesis.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site276

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functionheptose 7-phosphate kinase activity
Molecular Functionheptose-1-phosphate adenylyltransferase activity
Molecular Functionphosphotransferase activity, alcohol group as acceptor
Biological Processbiosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein HldE

Including 2 domains:

  • Recommended name
    D-beta-D-heptose 7-phosphate kinase
  • EC number
  • Alternative names
    • D-beta-D-heptose 7-phosphotransferase
    • D-glycero-beta-D-manno-heptose-7-phosphate kinase
  • Recommended name
    D-beta-D-heptose 1-phosphate adenylyltransferase
  • EC number
  • Alternative names
    • D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase

Gene names

    • Name
      rfaE2
    • Synonyms
      hldE
    • ORF names
      QH73_0008575

Organism names

  • Taxonomic identifier
  • Strain
    • VB511283
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Nostocales > Scytonemataceae > Scytonema

Accessions

  • Primary accession
    A0A9X5I4Q8

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-326Ribokinase
Domain14-316Carbohydrate kinase PfkB
Domain353-477Cytidyltransferase-like
Region353-487Cytidylyltransferase

Sequence similarities

In the C-terminal section; belongs to the cytidylyltransferase family.
In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    487
  • Mass (Da)
    53,153
  • Last updated
    2023-11-08 v1
  • Checksum
    E1959C41463A888E
MIAQQYLNKWTNLHVLVIGEAMLDCYLEGTSNRLCREAPVPIVDISSLKDVPGGAANTAANLARLGARVSFLSVIGNDEEGDRLKQTLQERGISTHNLIASTQRQTLLKQRISSDSQLLLRCDRGSIEIIDSQIENQLIENLSRLYSTCDAIVVSDYAGGILTPRIIQTIAQLQTQYPRTIVVDSKQLKNFKFINITAIKPNYQQAIQLLGISALKGKERIQQIADRGEKLLDFINTQLVAVTLDAEGAIIFERNNPPYIIPSHPMSNSQATGAGDTFVSGLTLALAAGAEGKLAASIAAATAAIVVTQPGTTTCSLSALHQSLSDNKKLVVSRDSLVTTIQEHRNWKHQIVFTNGCFDLLHLGHVTYLKQAKQLGDVLIVGVNSDESIRQLKGANRPVNCLSDRLAILSALESVDYVIPFAESTPSELIKIIRPDIYVKGGDYTPEMLPEVPLIEELGGEVKILPYVSNISTTAIVNRIYQTFVNS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JTJC03000002
EMBL· GenBank· DDBJ
NHC34712.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp