A0A9X4X859 · A0A9X4X859_LACJH

  • Protein
    Coenzyme A biosynthesis bifunctional protein CoaBC
  • Gene
    coaBC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site276CTP (UniProtKB | ChEBI)
Binding site286CTP (UniProtKB | ChEBI)
Binding site304-307CTP (UniProtKB | ChEBI)
Binding site323CTP (UniProtKB | ChEBI)
Binding site337CTP (UniProtKB | ChEBI)
Binding site341CTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentphosphopantothenoylcysteine decarboxylase complex
Molecular FunctionFMN binding
Molecular Functionmetal ion binding
Molecular Functionphosphopantothenate--cysteine ligase activity
Molecular Functionphosphopantothenoylcysteine decarboxylase activity
Biological Processcoenzyme A biosynthetic process
Biological Processpantothenate catabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Coenzyme A biosynthesis bifunctional protein CoaBC
  • Alternative names
    • DNA/pantothenate metabolism flavoprotein
    • Phosphopantothenoylcysteine synthetase/decarboxylase
      (PPCS-PPCDC
      )

Including 2 domains:

  • Recommended name
    Phosphopantothenoylcysteine decarboxylase
  • EC number
  • Short names
    PPC decarboxylase
    ; PPC-DC
  • Alternative names
    • CoaC
  • Recommended name
    Phosphopantothenate--cysteine ligase
  • EC number
  • Alternative names
    • CoaB
    • Phosphopantothenoylcysteine synthetase
      (PPC synthetase
      ; PPC-S
      )

Gene names

    • Name
      coaBC
    • ORF names
      BBP16_03080
      , GJU95_04430

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • BS15
    • LL8
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus

Accessions

  • Primary accession
    A0A9X4X859

Proteomes

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain1-173Flavoprotein
Region1-185Phosphopantothenoylcysteine decarboxylase
Domain181-366DNA/pantothenate metabolism flavoprotein C-terminal
Region186-402Phosphopantothenate--cysteine ligase

Sequence similarities

In the C-terminal section; belongs to the PPC synthetase family.
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    402
  • Mass (Da)
    43,639
  • Last updated
    2023-11-08 v1
  • Checksum
    A54612C9179F411F
MKATIYITGSIAAYKAISVVRDFQKEGHEVRVAMTEEAVHLIGTQTLAALTKHPVLTDLWKENRADKIQHIELADWTDIAVVVPATANFIAKIANGIADDAASTTFLATAAPKYVIPAMNSHMWSNPAFQRNLQQLKQDGIFVMDPDTGRLAEGYNGKGRMPEPAAIMNWVNSSLQVNDELAGKKVVITAGGTVSPLDPVRYLGNRSSGKMGLALANAALRAGAEVVLIVGHVSVPVPESSKMTVIHVETTEEMLAAVKKAFSTADALIMAAAVADYEPVNYIDHKIKKQDQGDKLKIYLKETPDILKTMGSLKQEQQVVVGFAAETNDLLENATKKLKNKNADMIVANNVSQGVFGSDRDKVTVLRKDKANENIAETTKVEIAKKIITLVAEELESRKVIK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP016400
EMBL· GenBank· DDBJ
AOG25933.1
EMBL· GenBank· DDBJ
Genomic DNA
WKKC01000012
EMBL· GenBank· DDBJ
MTE03017.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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