A0A9X3YXU8 · A0A9X3YXU8_9XANT

  • Protein
    Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
  • Gene
    glnE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Molecular Function[glutamate-ammonia-ligase] adenylyltransferase activity
Molecular FunctionATP binding
Molecular Functionligase activity
Molecular Functionmagnesium ion binding
Biological Processregulation of glutamine family amino acid metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
  • Alternative names
    • ATP:glutamine synthetase adenylyltransferase
    • ATase

Including 2 domains:

  • Recommended name
    Glutamine synthetase adenylyl-L-tyrosine phosphorylase
  • EC number
  • Alternative names
    • Adenylyl removase
      (AR
      ; AT-N
      )
  • Recommended name
    Glutamine synthetase adenylyl transferase
  • EC number
  • Alternative names
    • Adenylyl transferase
      (AT
      ; AT-C
      )

Gene names

    • Name
      glnE
    • ORF names
      NY667_01665

Organism names

Accessions

  • Primary accession
    A0A9X3YXU8

Proteomes

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-438Adenylyl removase
Domain40-274Glutamate-ammonia ligase adenylyltransferase repeated
Domain296-435PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Region448-938Adenylyl transferase
Domain546-788Glutamate-ammonia ligase adenylyltransferase repeated
Domain810-893PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase

Sequence similarities

Belongs to the GlnE family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    938
  • Mass (Da)
    102,357
  • Last updated
    2023-11-08 v1
  • Checksum
    A524157F45FD807F
MSPPIVSVSPALTALIERAVARVRHALPADQSWPGDDVDQRLEKVALASEFALDTLARQPALLQHLAQPDPPPLPLPLLDPAQPQAWPAQLRRYRSAESTRLVWRDVLELDSVDDTLAGATRLAETCLQCGLQALEQQFRDRHGQVLAEDGSVQRLVVFGLGKLGGGELNFSSDVDLVYAYPQSGQSDGARPLAAEEYFARLGQQLAKLLDETTADGFSHRVDLRLRPFGTAGRVALSFTGMDHYFQREGRDWERYAWLKARAVAGDIAAGEAWLETLRPFVYRRYLDFTALDGLRDMKAAITAEVARHDRLDDIKRGPGGIREIEFLAQSLQLIRGGREPTLRERRLLPALRALVAAGQMDADNGDALIEAYRFLRRLENRLQMLRDAQTHALPQAALDRERIALGLGYADWSALLQALAPQRARVAAEFAELLAPRVHATAPDALADYWRALPEGDAAPLAGIGLHDPAGAHQVLADFAQSSGVRALSDTAGARLDRVMPALLHAATRASQPDATVRRMLGLLQATLRRTSYLALLDEQPSALARLVDVLSRSALLAERLAAHPLLLDELLDTRISGPLPDRAALHTACADTLQIDDTEAALRELNERRLALSFRIALATLDGRQQPVDSTQQLAWLAEAVVQTVLQLARRELVAAHGQVPGGAFAIIGYGSLGGLELGFGSDLDLVFLYDHPREVEASDGKRPLEAGRWFARLAQKVMTLLGAETGAGRLYDIDVRLRPDGGKGALVSSLASYRDYQRDRAWTWEHQALVRARAVAGDAALCEAFVQVRRETLTRVRDPALLHEDVRKMRARMRSELDRSDAGRLDLKQGAGGLVDLEFVLQAGVLGQAAEHPAVLLACATPALIDALVHVQWLPAESAAPLHHAHATLVEAGLSCTLDRRPRLVVSTPPIRDACQIVAAIADAQQLRFPPGKGA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JANWTP010000002
EMBL· GenBank· DDBJ
MDC8636545.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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