A0A9X3MLM0 · A0A9X3MLM0_9VIBR

  • Protein
    Bifunctional aspartokinase/homoserine dehydrogenase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a metal cation (UniProtKB | Rhea| CHEBI:25213 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.

GO annotations

AspectTerm
Molecular Functionaspartate kinase activity
Molecular FunctionATP binding
Molecular Functionhomoserine dehydrogenase activity
Molecular FunctionNADP binding
Biological Processhomoserine biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processthreonine biosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional aspartokinase/homoserine dehydrogenase

Including 2 domains:

  • Recommended name
    Aspartokinase
  • EC number
  • Recommended name
    Homoserine dehydrogenase
  • EC number

Gene names

    • ORF names
      OH463_24905

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NFR
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Vibrio

Accessions

  • Primary accession
    A0A9X3MLM0

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-272Aspartate/glutamate/uridylate kinase
Domain457-592Aspartate/homoserine dehydrogenase NAD-binding
Domain600-795Homoserine dehydrogenase catalytic

Sequence similarities

In the C-terminal section; belongs to the homoserine dehydrogenase family.
In the N-terminal section; belongs to the aspartokinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    802
  • Mass (Da)
    87,824
  • Last updated
    2023-11-08 v1
  • Checksum
    FB2F3847B919A761
MTVQRQLHKFGGSSLANPECYQRVVGILKEYSAENDLVVVSAAGKTTNRLIEFLEGLDKDGRIAHEALQNLRLFQTELVEALLEGEAQTQVLASLQDEFSTLAELTAPLTEAQKAAVLGHGEVWSSRLLAALLSQQDLPAVAQDSRAFLRAEAGTQPEVDRARSYALIKEALTQHSHKRVIITGFMAQNEVGETVLLGRNGSDYSATVIGALAEVNTVTIWSDVAGVYSADPRLVSDACLLPLLRLDEASELARLAAPVLHSRTLQPVAQSTMDLNLKCSYQPESGSTRIERVLASGRGAKIITSLDEVLLVQLSFIHGHDFERAQKEVLQALKRAQLEPLAFEAQQDQQTLRLAYTAEIAGGALTYLQELAVEAEIKLKEGYSLLAAVGAGVTKNANHCFGFYQQLKHAPVEFISETESGLSLVAVLRRAEVEELVQCIHSQLFQAQKRVAVALCGKGNIGSSWLSLFAEQKEELEKRHGMSFDLVAVVDSQTYWFDENGIDAATVAQRFDDESIENDGNWLTKLGAIQNFDEAVVLDVTASKELATRYVEIAQQGIHLISANKVAGSADSQYYHQVQDAFAKIGRHWLYNATVGAGLPINHTVRDLRESGDDVVALSGIFSGTLSWLFQQFDGSVPFAELVDLAWQQGLTEPDPRSDLDGSDVMRKLVILARESGLSIEPESVKVESLVPEELRELSLDAFFDQGDILSEILQERLTKAQKNDQVLRYVARLERNGKATVGVEALSREHALANLLPCDNIFAIESKWYKDNPLVIRGPGAGREVTAGAIQSDLNRLAGLF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAPPTN010000021
EMBL· GenBank· DDBJ
MDA0135613.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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