A0A9X0PWZ0 · A0A9X0PWZ0_9ESCH
- ProteinBifunctional protein PutA
- GeneputA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1320 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Oxidizes proline to glutamate for use as a carbon and nitrogen source.
Catalytic activity
- L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH + 2 H+
Cofactor
Pathway
Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 883 | ||||
Active site | 917 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic side of plasma membrane | |
Molecular Function | 1-pyrroline-5-carboxylate dehydrogenase activity | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | proline dehydrogenase activity | |
Molecular Function | sequence-specific DNA binding | |
Biological Process | proline biosynthetic process | |
Biological Process | proline catabolic process to glutamate |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameBifunctional protein PutA
Including 2 domains:
- Recommended nameProline dehydrogenase
- EC number
- Alternative names
- Recommended nameDelta-1-pyrroline-5-carboxylate dehydrogenase
- EC number
- Short namesP5C dehydrogenase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionA0A9X0PWZ0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 11-43 | PutA RHH | |||
Domain | 89-136 | Proline utilization A proline dehydrogenase N-terminal | |||
Domain | 148-259 | Proline dehydrogenase PutA | |||
Domain | 268-569 | Proline dehydrogenase | |||
Domain | 659-1103 | Aldehyde dehydrogenase | |||
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
In the C-terminal section; belongs to the aldehyde dehydrogenase family.
In the N-terminal section; belongs to the proline dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,320
- Mass (Da)143,916
- Last updated2023-11-08 v1
- MD5 Checksum4F27BCF7FD2D101E5E118A216D0CF5CE
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JABWMT020000010 EMBL· GenBank· DDBJ | MBB2318514.1 EMBL· GenBank· DDBJ | Genomic DNA |