A0A9W9ZBH3 · A0A9W9ZBH3_9CNID

Function

function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site35-40ATP (UniProtKB | ChEBI)
Binding site61a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site82-84a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site109-112a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site116CMP (UniProtKB | ChEBI)
Binding site150ATP (UniProtKB | ChEBI)
Binding site156a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site167a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site195ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Function(d)CMP kinase activity
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological ProcessCDP biosynthetic process
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UMP-CMP kinase
  • EC number
  • Alternative names
    • Deoxycytidylate kinase
      (CK
      ; dCMP kinase
      )
    • Uridine monophosphate/cytidine monophosphate kinase
      (UMP/CMP kinase
      ; UMP/CMPK
      )

Gene names

    • Name
      CMPK1
    • ORF names
      OS493_021949

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • USNM1676648
  • Taxonomic lineage
    Eukaryota > Metazoa > Cnidaria > Anthozoa > Hexacorallia > Scleractinia > Caryophylliina > Caryophylliidae > Desmophyllum

Accessions

  • Primary accession
    A0A9W9ZBH3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region149-159LID

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    213
  • Mass (Da)
    24,009
  • Last updated
    2023-11-08 v1
  • Checksum
    D148C95167627BE4
MFHLSCFLGRITSSVQSAMSSAVKPIVIFVLGGPGAGKGTQCERIVKKFGYIHLSAGDLLREERASGSENGDLIESYIREGKIVPVEITISLIEKAMNKNSVKKFLIDGFPRNEDNLQGWNRVMNGKVDMKCVLFFECSEDECIKRIMERGKSSGRSDDNIESLRKRFHTYETQTMPIIEHYQKQGLVRKIQAIKSPDEVFEEVQNILTSLGE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MU826364
EMBL· GenBank· DDBJ
KAJ7378647.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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