A0A9W9Z4G4 · A0A9W9Z4G4_9CNID

  • Protein
    Phosphatidylserine synthase
  • Gene
    PTDSS2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
    This reaction proceeds in the forward direction.
  • 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
    This reaction proceeds in the forward direction.
  • 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine
    EC:2.7.8.29 (UniProtKB | ENZYME | Rhea)

Pathway

Lipid metabolism.
Phospholipid metabolism; phosphatidylserine biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular FunctionL-serine-phosphatidylethanolamine phosphatidyltransferase activity
Biological Processphosphatidylserine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylserine synthase
  • EC number
  • Alternative names
    • Serine-exchange enzyme

Gene names

    • Name
      PTDSS2
    • ORF names
      OS493_011172

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • USNM1676648
  • Taxonomic lineage
    Eukaryota > Metazoa > Cnidaria > Anthozoa > Hexacorallia > Scleractinia > Caryophylliina > Caryophylliidae > Desmophyllum

Accessions

  • Primary accession
    A0A9W9Z4G4

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane57-79Helical
Transmembrane91-110Helical
Transmembrane122-142Helical
Transmembrane312-331Helical
Transmembrane343-360Helical
Transmembrane380-398Helical
Transmembrane410-429Helical

Keywords

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region447-469Disordered

Sequence similarities

Belongs to the phosphatidyl serine synthase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    469
  • Mass (Da)
    53,827
  • Last updated
    2023-11-08 v1
  • Checksum
    2FB0D9CE5E870337
MGKPKEGTSHHNGQTHDKDIVKANGHAVEEDDRPFSISCEWDIKQTQQFTDDGTNTYFWRAHTVTILLILLCIVVYVGAFEKPNEDGEYNAKRGLIACIAVFLLFGVTQISDGPFKRPHPAFWRIILCLSVVYELALIFLLFQTADDARQMLKYIDKDLGKPLPEQSYGEDCRLYTPGHPKGSFHTFLEKCDVFLPAHFFGWWAKALIIRDYWLLTVISVFFEILEYSLEHQLPNFSECWWDHWIMDVLVCNGLGVYLGMKTCEYLGNKPYHWRGLWNIPTYSGKFQRVAAQFTPYSWTSYDWKATTSLKRWLAVCGIAAVFLTAELNLFYLKFILWIPPPHLIMQVRMALFLGIGAVSLNETFRYMDDPTCKRFGQQAWVVAAIVSTEVLICIKFGWETLSIPLPMHVTAFWTLSFGIWAAWTVWTFWPSIIGGFGVHHGSESKNGGISNAEHSNGVITNTEHRPKHE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MU826830
EMBL· GenBank· DDBJ
KAJ7373568.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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