A0A9W9Y863 · A0A9W9Y863_9CNID

  • Protein
    Tryptophan 2,3-dioxygenase
  • Gene
    TDO2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 1 heme group per subunit.

Pathway

Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site162substrate

GO annotations

AspectTerm
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functiontryptophan 2,3-dioxygenase activity
Biological Processtryptophan catabolic process to kynurenine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tryptophan 2,3-dioxygenase
  • EC number
  • Short names
    TDO
  • Alternative names
    • Tryptamin 2,3-dioxygenase
    • Tryptophan oxygenase
      (TO
      ; TRPO
      )
    • Tryptophan pyrrolase
    • Tryptophanase

Gene names

    • Name
      TDO2
    • ORF names
      OS493_032659

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • USNM1676648
  • Taxonomic lineage
    Eukaryota > Metazoa > Cnidaria > Anthozoa > Hexacorallia > Scleractinia > Caryophylliina > Caryophylliidae > Desmophyllum

Accessions

  • Primary accession
    A0A9W9Y863

Proteomes

Interaction

Subunit

Homotetramer. Dimer of dimers.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-21Disordered

Sequence similarities

Belongs to the tryptophan 2,3-dioxygenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    448
  • Mass (Da)
    51,862
  • Last updated
    2023-11-08 v1
  • Checksum
    8E8CB71CB56ADC3A
MSCPYAQDSNGEASAPVGRPGDEKRMNYGDYLQLNTLLDCQKPASTTFGDSTVHDELLFIVVHQAYELWFKQIIHELDSIRDIFTLEVEELGMDERKMLVLISRLSRILQIQKLLRDQIMILETMTPLDFMEFRDYLAPASGFQSLQFRLIENKLGINKIHRIRYNYQDYSKAFDSQDGKQLEESESTPSLQELVQRWLERTPGLEENGFDFWRKYKRSVQDMLKTQKAEAEAVEDEEMKAYLLKEVKKQEDHFDTIFSEERHNQFVSRGERRFSHKAMQGALMIYFYRDEPRFNQPFQILQLLMDIDSHLIKWRYNHLMMVQRMIGSKLGTGGTSGYQYLRSTVSDRYKVFVDLFNLSNFLIPRDRIPPLSSSMKVRLRTALVEGRLYDSDSALFSDSSEEEQVSTPSPPGIKNAATIASATEAKRLAISQGGKLSEHAGDVDKLCS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MU827818
EMBL· GenBank· DDBJ
KAJ7323088.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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