A0A9W9Y863 · A0A9W9Y863_9CNID
- ProteinTryptophan 2,3-dioxygenase
- GeneTDO2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids448 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Catalytic activity
- L-tryptophan + O2 = N-formyl-L-kynurenine
Cofactor
Note: Binds 1 heme group per subunit.
Pathway
Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 162 | substrate | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | tryptophan 2,3-dioxygenase activity | |
Biological Process | tryptophan catabolic process to kynurenine |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTryptophan 2,3-dioxygenase
- EC number
- Short namesTDO
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Cnidaria > Anthozoa > Hexacorallia > Scleractinia > Caryophylliina > Caryophylliidae > Desmophyllum
Accessions
- Primary accessionA0A9W9Y863
Proteomes
Interaction
Subunit
Homotetramer. Dimer of dimers.
Structure
Sequence
- Sequence statusComplete
- Length448
- Mass (Da)51,862
- Last updated2023-11-08 v1
- Checksum8E8CB71CB56ADC3A
Keywords
- Technical term