A0A9W8B6M0 · A0A9W8B6M0_9FUNG

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Ni cation (UniProtKB | Rhea| CHEBI:25516 )

Note: Binds 2 nickel ions per subunit.

Pathway

Nitrogen metabolism; urea degradation; CO2 and NH3 from urea (urease route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site410Ni2+ 1 (UniProtKB | ChEBI)
Binding site412Ni2+ 1 (UniProtKB | ChEBI)
Binding site493Ni2+ 1 (UniProtKB | ChEBI); via carbamate group
Binding site493Ni2+ 2 (UniProtKB | ChEBI); via carbamate group
Binding site495substrate
Binding site522Ni2+ 2 (UniProtKB | ChEBI)
Binding site548Ni2+ 2 (UniProtKB | ChEBI)
Active site596Proton donor
Binding site636Ni2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componenturease complex
Molecular Functionnickel cation binding
Molecular Functionurease activity
Biological Processurea catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Urease
  • EC number
  • Alternative names
    • Urea amidohydrolase

Gene names

    • Name
      URE1
    • ORF names
      H4R34_003235

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • RSA 567
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Zoopagomycota > Kickxellomycotina > Dimargaritomycetes > Dimargaritales > Dimargaritaceae > Dimargaris

Accessions

  • Primary accession
    A0A9W8B6M0

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue493N6-carboxylysine

Post-translational modification

Carbamylation allows a single lysine to coordinate two nickel ions.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain405-880Urease

Sequence similarities

In the C-terminal section; belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    880
  • Mass (Da)
    95,022
  • Last updated
    2023-11-08 v1
  • Checksum
    201C3D37B06F34BE
MHLLPRELDKLRLVQVGHLAQRRLAQGIRLNPPEATALIATRVLDLMRTGKHSVAELMSLGGQMLGYRHVLPAAPVLVKDVQVEGTVRNGCFLVTINEPIATVDGDLPLALGGSFLPVPDNATVFPWNDEIAKEYHPDRQPGALFAQAADIVLHPNRPRRLLRVTNDGDRPIQVGSHYHLIESNASLRLDRALAYGMKLDIPAGTAVRFEPGETKTVTLVAIGGNRVISGGNGLASGPVDAALSGREAAMQQVQQHGFAHREDPQRTSRDQLKPYQLDRHTYADMFGPTTGDRLRLGDTELILEVERDYTCYGDECKFGGGKVLREGMGQATHAKPESVLDLVITNALIVDYTGIYKADIGIRSGMIVGIGKAGNPDVMDGVTERMTVGASTDVIGAEGMIVTAGGIDTHVHFIGLDICTEALANGLTTLIGGGAGPTTGSNATTCTAGQFHTQFMLEATDTIPLNLGFTGKGNTSAPEEIVVQIEAGAIGLKLHEDWGSTPQAIDNCLSVCEQYDVQVNIHTDTLNESGFVEETIAAFKGRTIHTYHSEGAGGGHAPDIITVCSLPNVLPSSTNPTRPYTLNTLDEHIDMLMVCHHLSKNIPEDVAFAESRIRAETIAAEDVLHDMGAISIISSDSQAMGRIGEVISRTWRTAHKMKVQRGHLAPGADDASTFPTAIPVQRSPEKLTQHQSTINSSEGAHPNFAHPSDNFRIRRYVAKYTINPAIAHGISHIVGSVEVGKLADLVMYRPQYFGSRPHIVLKGGTIAWSLLGDANGSIPTTEPMVLRKAFGGLPNAAKRNSLAFISQASIDRDIATNYRVSKRLVPVKRCRQVTKRDMKLNAAMPKLHVDPETYTVTADRQICSCEAVGELPLCQNYNLF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JANBQB010000282
EMBL· GenBank· DDBJ
KAJ1978354.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp