A0A9W7C6N6 · A0A9W7C6N6_9STRA

Function

function

Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site413-418ITP (UniProtKB | ChEBI)
Binding site440Mg2+ (UniProtKB | ChEBI)
Binding site452ITP (UniProtKB | ChEBI)
Binding site468Mg2+ (UniProtKB | ChEBI)
Binding site468-469ITP (UniProtKB | ChEBI)
Binding site544-547ITP (UniProtKB | ChEBI)
Binding site572ITP (UniProtKB | ChEBI)
Binding site577-578ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionamino acid kinase activity
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      TrLO_g14075

Organism names

  • Taxonomic identifier
  • Strain
    • NIES 3700
  • Taxonomic lineage
    Eukaryota > Sar > Stramenopiles > Ochrophyta > Bolidophyceae > Parmales > Triparmaceae > Triparma

Accessions

  • Primary accession
    A0A9W7C6N6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain53-274Aminoglycoside phosphotransferase

Sequence similarities

Belongs to the HAM1 NTPase family.
Belongs to the aminoglycoside phosphotransferase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    595
  • Mass (Da)
    65,475
  • Last updated
    2023-11-08 v1
  • Checksum
    EBFE05AF3B599609
MTSETPSDEVRRKWLKPKCTFEDVMAVLKSSFAKSLDLANNATISITKKLDSYDDENFLLSHTTSTNITTKYLVKVHNGVESESASIIDYQNKIMLHLNGADGITTTTPLTCDSGDLCVTTPLPVQSPSHSPSPLCVRLLTYIEGTPMAYKNVTADLLHDAGEYLANVDSSLDNFDHPAAKRFHAWDQRNTTSLREFVQYIQTQERQAMISDIIDVFEKTVLVDDEKLRKGVLQSDFNDANIILDGSDKLAGVIDFGDSVYSWRVLDLSVAMAYAMLSSYGKTCHSLAAASSFLRGFNSKYPLDAVEKKHLRVLVACRLACSATLGAYSYSQDPSNKYLLLHAEPCWNALEMLWKEVPAQVVESMFGLACNPPAAGGTNDIAIPDPSVKDILVSARGKRERTEGEGDKIVFVTGNKKKLEEVKQILKGCELTNFKLDLPELQGDPLYVSKEKCVLAAKEIGGAVITEDTSLCFNALNGMPGPYIKWFLESCGHGGLNKMLDGFEDRSAYAQTVVAYCGGEGQEVLLFDGRTNGVIVEARGPTDFGWDPIFECAEGGKTTNGLTYAEMDKAEKNKVSHRGKAFEQLKAYLRKEGKM

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BRXW01000050
EMBL· GenBank· DDBJ
GMI02862.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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