A0A9W7BFD6 · A0A9W7BFD6_9STRA
- Protein4-trimethylaminobutyraldehyde dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids540 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines.
Catalytic activity
- (5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD+ = (5-hydroxyindol-3-yl)acetate + 2 H+ + NADH
- 3,4-dihydroxyphenylacetaldehyde + H2O + NAD+ = 3,4-dihydroxyphenylacetate + 2 H+ + NADH
- H2O + NAD+ + pentanal = 2 H+ + NADH + pentanoate
- H2O + NAD+ + propanal = 2 H+ + NADH + propanoate
- H2O + NAD+ + spermine monoaldehyde = 2 H+ + N-(2-carboxyethyl)spermidine + NADH
- H2O + hexanal + NAD+ = 2 H+ + hexanoate + NADH
- H2O + imidazole-4-acetaldehyde + NAD+ = 2 H+ + imidazole-4-acetate + NADH
- acrolein + H2O + NAD+ = acrylate + 2 H+ + NADH
- butanal + H2O + NAD+ = butanoate + 2 H+ + NADH
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 287 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | aldehyde dehydrogenase (NAD+) activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-trimethylaminobutyraldehyde dehydrogenase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Stramenopiles > Ochrophyta > Bolidophyceae > Parmales > Triparmaceae > Triparma
Accessions
- Primary accessionA0A9W7BFD6
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 49-527 | Aldehyde dehydrogenase | ||||
Sequence: QSGEEMSNFSPGTGALISTVEVATQATIDAAVASAQAAFPAWSALSGAERGRILTRAAVLIREYNSEMSLLESVDAGIPVSETEFVQVLGGADCFEYYGGLASNACVTGQMMDTPHAGGHKDSFCYTRREPLGVCAGIGAWNYPVLVMSWKVAPALACGNTFVYKPSECTPLTALKIAEILKEAGLPDGVFNVVVGDRTTGPMLTRHSDVKKLSFTGSTETGIRIVKEAAETLKKVTMELGGKSPLLVFEDADVDNAVGAAMMSNWYTQGEICSNATRVFVHKSVKEEFVRKLVERTKQLKVGDPLDPLTHVGAMIMPPDNKTGHMDRVIGYIERAKADPRNKLILGGNTHTIEVAGGKGGSGNEGCYVEPTIFECTDDNSELVKEEVFGPVMSILEFEDEADAVERANDTIYGLGAGIMTNNLARAHRVAKQFQSGNVWINNYNLTPSEMPFGGYGMSGYGRECGTYAIDNYTQIKNV |
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length540
- Mass (Da)58,161
- Last updated2023-11-08 v1
- ChecksumD20DE2B86A17A9E2