A0A9W5S234 · A0A9W5S234_9BACL

Function

function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Features

Showing features for binding site.

166750100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site46-53ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentexcinuclease repair complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Molecular Functionexcinuclease ABC activity
Biological Processnucleotide-excision repair
Biological ProcessSOS response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    UvrABC system protein B
  • Short names
    Protein UvrB
  • Alternative names
    • Excinuclease ABC subunit B

Gene names

    • Name
      uvrB
    • ORF names
      BG53_00815

Organism names

  • Taxonomic identifier
  • Strain
    • CE1
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Paenibacillaceae > Paenibacillus

Accessions

  • Primary accession
    A0A9W5S234

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.

Family & Domains

Features

Showing features for domain, motif, coiled coil.

Type
IDPosition(s)Description
Domain33-167Helicase ATP-binding
Motif99-122Beta-hairpin
Coiled coil264-298
Domain437-603Helicase C-terminal
Coiled coil625-652
Domain629-664UVR

Domain

The beta-hairpin motif is involved in DNA binding.

Sequence similarities

Belongs to the UvrB family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    667
  • Mass (Da)
    76,182
  • Last updated
    2023-11-08 v1
  • MD5 Checksum
    FEB67B6B82E1920F49D8EDDDE91FA24C
MGDGLEVKERMFELLSEYKPQGDQPAAIKQLVEGVKGGKRHQTLLGATGTGKTYTVANMIAELNRPTLVIAHNKTLAAQLCSEFQEFFPNNAVSYFVSYYDYYQPEAYIPSSDTYIEKDSSINDEIDKLRHSATSSLFERRDVIVVASVSCIYGLGSPMEYKNLVLSLRVGMEKPRNTILHKLVDIQYQRNDINFVRGTFRVRGDVIEIFPVANNERAIRVELFGDDIERITEIDTLTGEIVGERDHVAIFPASHFVTHQDTMRVALQNIERELEERLAELREQGKLLEAQRLEQRTRYDIEMMQEMGFCSGIENYSGPLTFRERGATPYTLLDYFPDDMLIVVDESHVTLPQIRAMYNGDRARKEVLVNHGFRLPSAMDNRPLRFEEFEEKAGQLVYVSATPGPYEIEHTPEMIQQIIRPTGLLDPIIEVRKTKGQIDDLLGEIRDRIAKDERVLVTTLTKKMAEDLTDYLKEVGIKVRYLHSDIKTLERMAILRDLRVGTFHVLVGINLLREGLDLPEVSLVAILDADKEGFLRSERSLIQTIGRAARNSEGRVIMYGDKITDSMDKAIRETERRREIQIAYNEKHGITPQTIRKKVHDVIEATKVAEQKADYLANEYGKMSKKEKQSLIQRLEAEMKEAAKSLQFERAAELRDALLELKAEVGA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JFHU01000110
EMBL· GenBank· DDBJ
EXX89026.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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