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A0A9W3P5Q9 · A0A9W3P5Q9_BACTU

Function

function

Catalyzes the conversion of lactate to pyruvate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Activity regulation

Allosterically activated by fructose 1,6-bisphosphate (FBP).

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site12-17NAD+ (UniProtKB | ChEBI)
Binding site16NAD+ (UniProtKB | ChEBI)
Binding site37NAD+ (UniProtKB | ChEBI)
Binding site42NAD+ (UniProtKB | ChEBI)
Binding site68NAD+ (UniProtKB | ChEBI)
Binding site82-83NAD+ (UniProtKB | ChEBI)
Binding site85substrate
Binding site91substrate
Binding site98NAD+ (UniProtKB | ChEBI)
Binding site121-123NAD+ (UniProtKB | ChEBI)
Binding site123-126substrate
Binding site146NAD+ (UniProtKB | ChEBI)
Binding site151-154substrate
Binding site156beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Binding site171beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Active site178Proton acceptor
Binding site232substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionL-lactate dehydrogenase activity
Biological Processglycolytic process
Biological Processlactate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-lactate dehydrogenase
  • EC number
  • Short names
    L-LDH

Gene names

    • Name
      ldh
    • ORF names
      BTF1_22990

Organism names

  • Taxonomic identifier
  • Strain
    • HD-789
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus > Bacillus cereus group

Accessions

  • Primary accession
    A0A9W3P5Q9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue223Phosphotyrosine

Keywords

Interaction

Subunit

Homotetramer.

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-145Lactate/malate dehydrogenase N-terminal
Domain148-312Lactate/malate dehydrogenase C-terminal

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    314
  • Mass (Da)
    34,620
  • Last updated
    2023-11-08 v1
  • MD5 Checksum
    1F4E6000F9D45376F0DA61708E5F2637
MKKGINRVVLVGTGAVGCSYAYSMINQGVAEEFVLVDVNEAKAEGEAMDLSHAVPFSPSPTKVWSGSYADCKDADLVVITAGLPQKPGETRLDLVEKNTKIFKQIVRGIMDSGFDGIFLIATNPVDILTYVTWKESGLPKERVIGSGTTLDSARFRYMLGDYLDVDPRNVHAYIVGEHGDTELPVWSHATIGVQKLETILANNEQYKQEDLDKIFENVRDAAYHIIERKGATYYGIGMSLLRVTKAILNNENSVLTVSAYLEGQYGEKDAYVGVPAVINREGVREIVELELNEEEKAKFAHSVKVLKETMAPVL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP003763
EMBL· GenBank· DDBJ
AFQ28765.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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