A0A9R1CPA8 · A0A9R1CPA8_9TREE
- ProteinHomoaconitase, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids728 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
Catalytic activity
- (2R,3S)-homoisocitrate = cis-homoaconitate + H2O
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | homoaconitate hydratase activity | |
Molecular Function | metal ion binding | |
Biological Process | lysine biosynthetic process via aminoadipic acid |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomoaconitase, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus > Cryptococcus gattii species complex
Accessions
- Primary accessionA0A9R1CPA8
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 36-473 | Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha | ||||
Sequence: KIVQKYAVGLSEGVKVRAGDYVMIKPEHVMTHDNTGPVISKFLSLSCSKLDNPRQPVFALDHDVQNQSETNQKKYKKIQAFAKEHGVDFYPAGRGIGHQIIVEEGYAWPGKMVVASDSHSNHYGGVGCLGTAIVRTDAAGIWATGKFWWQIPRIVSVSLDGRLSPGVTGKDVIVALAGLFNKDEVLNAAIEFTGSGVEHLSIDERLTIANMTTEWGAVAGVFPVDDKLKVWYQGIIRKAELRKFISPAVPSTAGAEIHPRLNASRLDDAMTNKVVADPGAHYAARLSLDLSTLVPHVSGPNSVKVATALPKLLDPPIPINKAYLVSCTNSRASDIASAAQVLRGKKVAPGVEFYIAAASSRVQEDAEAAGDWQTLIDAGAKTLPAGCGPCIGLGVGLLEKGEVGISATNRNYKGRMGSPDAIAYLASPAVVAASAAKG | ||||||
Domain | 595-646 | Aconitase A/isopropylmalate dehydratase small subunit swivel | ||||
Sequence: ILLSGYNFGTGSSREQAATAIKNAGIPLVICGSFGDIFKRNSINNGLILIES |
Sequence similarities
Belongs to the aconitase/IPM isomerase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length728
- Mass (Da)77,804
- Last updated2023-09-13 v1
- ChecksumAD0A33541EE52F83