A0A9R1CPA8 · A0A9R1CPA8_9TREE

Function

function

Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionhomoaconitate hydratase activity
Molecular Functionmetal ion binding
Biological Processlysine biosynthetic process via aminoadipic acid

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homoaconitase, mitochondrial
  • EC number
  • Alternative names
    • Homoaconitate hydratase

Gene names

    • ORF names
      D1P53_000725

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MF34
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus > Cryptococcus gattii species complex

Accessions

  • Primary accession
    A0A9R1CPA8

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain36-473Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Domain595-646Aconitase A/isopropylmalate dehydratase small subunit swivel

Sequence similarities

Belongs to the aconitase/IPM isomerase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    728
  • Mass (Da)
    77,804
  • Last updated
    2023-09-13 v1
  • Checksum
    AD0A33541EE52F83
MVAIPRLARLSAPAWALGARGRFYATVSTPQTLVEKIVQKYAVGLSEGVKVRAGDYVMIKPEHVMTHDNTGPVISKFLSLSCSKLDNPRQPVFALDHDVQNQSETNQKKYKKIQAFAKEHGVDFYPAGRGIGHQIIVEEGYAWPGKMVVASDSHSNHYGGVGCLGTAIVRTDAAGIWATGKFWWQIPRIVSVSLDGRLSPGVTGKDVIVALAGLFNKDEVLNAAIEFTGSGVEHLSIDERLTIANMTTEWGAVAGVFPVDDKLKVWYQGIIRKAELRKFISPAVPSTAGAEIHPRLNASRLDDAMTNKVVADPGAHYAARLSLDLSTLVPHVSGPNSVKVATALPKLLDPPIPINKAYLVSCTNSRASDIASAAQVLRGKKVAPGVEFYIAAASSRVQEDAEAAGDWQTLIDAGAKTLPAGCGPCIGLGVGLLEKGEVGISATNRNYKGRMGSPDAIAYLASPAVVAASAAKGVICGPDSMDLNQLPQYEQPKFSIIEEDAAGEEKPVEIDEASLEPLLEGFPAYFEGPLLFAPQDNLTTDGMYPGKYTYQDDITPERQAEVVMENYDPTFAATARELRTTLPTVSSPSTLPGAILLSGYNFGTGSSREQAATAIKNAGIPLVICGSFGDIFKRNSINNGLILIESPSLIKDMTERFAKDGVRNQGGKDGKLTVVPEGWRIKVDSQRGLVTVCMGEEGEKTYPAAKVGRSVQELWVNGGLEGFIRASL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VHDQ01000002
EMBL· GenBank· DDBJ
KAE8543236.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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