A0A9R1CL38 · A0A9R1CL38_9TREE
- ProteinDouble-strand break repair protein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids707 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex 1 mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is 2 required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.
Cofactor
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 150 | Proton donor | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | Mre11 complex | |
Molecular Function | 3'-5'-DNA exonuclease activity | |
Molecular Function | DNA endonuclease activity | |
Molecular Function | manganese ion binding | |
Biological Process | double-strand break repair | |
Biological Process | meiotic cell cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameDouble-strand break repair protein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus > Cryptococcus gattii species complex
Accessions
- Primary accessionA0A9R1CL38
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-19 | Polar residues | ||||
Sequence: MSVPNRVPDSQTSSETGDE | ||||||
Region | 1-23 | Disordered | ||||
Sequence: MSVPNRVPDSQTSSETGDEPPLS | ||||||
Domain | 321-498 | Mre11 DNA-binding | ||||
Sequence: FQLEELPLKTVRPFELDEVVLSYAAEQGAVDLNDRDSITSFLREQVEALILQAKKNWKERNNGSTKNMMLPLIRLKVETTDAKEMVNPVRFGQEYVNRVANPRDILQYYRKKKSERKHKNNPDMPDIDNDEWEEDPESLTADERLSKLRMATLVKQYLQAQSLDVLVENGMEEAVMRF | ||||||
Region | 431-455 | Disordered | ||||
Sequence: KKKSERKHKNNPDMPDIDNDEWEED | ||||||
Region | 543-707 | Disordered | ||||
Sequence: EYNRYADSNPIPAQDIKGKNKQQDSDVDSMMASDDMDLDEMPTQQRVPGRRATAKQPVKSAKGKSKQPLFDDASEEEEKEDEEEEKDEEPVPKKGRGRAAAASTKKAPKKAPARTPAKSTTKTPARRAASQSSTGRGITQSQLSFSRSGAGKAAAVPIELSSDED | ||||||
Compositional bias | 658-690 | Polar residues | ||||
Sequence: PAKSTTKTPARRAASQSSTGRGITQSQLSFSRS |
Sequence similarities
Belongs to the MRE11/RAD32 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length707
- Mass (Da)78,855
- Last updated2023-09-13 v1
- Checksum2DACAA50C05424F9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-19 | Polar residues | ||||
Sequence: MSVPNRVPDSQTSSETGDE | ||||||
Compositional bias | 658-690 | Polar residues | ||||
Sequence: PAKSTTKTPARRAASQSSTGRGITQSQLSFSRS |