A0A9R1CL38 · A0A9R1CL38_9TREE

  • Protein
    Double-strand break repair protein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex 1 mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is 2 required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site150Proton donor

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular ComponentMre11 complex
Molecular Function3'-5'-DNA exonuclease activity
Molecular FunctionDNA endonuclease activity
Molecular Functionmanganese ion binding
Biological Processdouble-strand break repair
Biological Processmeiotic cell cycle

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Double-strand break repair protein

Gene names

    • ORF names
      D1P53_001091

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MF34
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus > Cryptococcus gattii species complex

Accessions

  • Primary accession
    A0A9R1CL38

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-19Polar residues
Region1-23Disordered
Domain321-498Mre11 DNA-binding
Region431-455Disordered
Region543-707Disordered
Compositional bias658-690Polar residues

Sequence similarities

Belongs to the MRE11/RAD32 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    707
  • Mass (Da)
    78,855
  • Last updated
    2023-09-13 v1
  • Checksum
    2DACAA50C05424F9
MSVPNRVPDSQTSSETGDEPPLSIVEPDLENCFRILIATDNHIGYAEKDPVRGQDSINTFREILELARDHEVDFILLAGDLFHENRPSRTCMHQTIALLREFTLGDKPIEFELLSDPMDGSTPGFSFPAVNYEDPNINIAIPVFSIHGNHDDPQGTGPEGALCALDVLSVSGVLNYFGKSDLVADESAADNSEKGIQIRPVLLRKGTTHVALYGCGNIRDQRMYQELRANKVKMFMPTGGDVPDSECVRHGPQNYVPENMFDDSMRLVIWGHEHDCRITPESVADRSYFITQPGSSVATSLAPGEAIPKHVGLLSIQGSQFQLEELPLKTVRPFELDEVVLSYAAEQGAVDLNDRDSITSFLREQVEALILQAKKNWKERNNGSTKNMMLPLIRLKVETTDAKEMVNPVRFGQEYVNRVANPRDILQYYRKKKSERKHKNNPDMPDIDNDEWEEDPESLTADERLSKLRMATLVKQYLQAQSLDVLVENGMEEAVMRFVDKDDKDAIKDFVADTLRMVGRKMKEKEVKEDDVDLAMAEAKEKEYNRYADSNPIPAQDIKGKNKQQDSDVDSMMASDDMDLDEMPTQQRVPGRRATAKQPVKSAKGKSKQPLFDDASEEEEKEDEEEEKDEEPVPKKGRGRAAAASTKKAPKKAPARTPAKSTTKTPARRAASQSSTGRGITQSQLSFSRSGAGKAAAVPIELSSDED

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-19Polar residues
Compositional bias658-690Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VHDQ01000004
EMBL· GenBank· DDBJ
KAE8542317.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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