A0A9R1CGT7 · A0A9R1CGT7_9TREE

Function

function

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site80Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site109Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Molecular Functionlactoylglutathione lyase activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lactoylglutathione lyase
  • EC number
  • Alternative names
    • Glyoxalase I

Gene names

    • ORF names
      D1P53_004580

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MF34
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus > Cryptococcus gattii species complex

Accessions

  • Primary accession
    A0A9R1CGT7

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-143VOC

Sequence similarities

Belongs to the glyoxalase I family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    143
  • Mass (Da)
    16,143
  • Last updated
    2023-09-13 v1
  • Checksum
    9693841ADD5A5AD7
MSTAASNPATYKFNHTMIRIKDPKVSLPFYEKVLGMKVYYEAPGGDFTNYFLAFANGFDGVDLNKDNVREKLFEREGILELCHNWGTENDANFKGYASGNEEPGRGFGHVCISVDNLEAACKRFDELGVKFKKRPEEGRMRGV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VHDQ01000011
EMBL· GenBank· DDBJ
KAE8539479.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help