A0A9R1CFS8 · A0A9R1CFS8_9TREE
- ProteinLysophospholipase NTE1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1379 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.
Catalytic activity
- a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1107 | Nucleophile | ||||
Sequence: S | ||||||
Active site | 1225 | Proton acceptor | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | lysophospholipase activity | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidylcholine metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLysophospholipase NTE1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus > Cryptococcus gattii species complex
Accessions
- Primary accessionA0A9R1CFS8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-30 | Helical | ||||
Sequence: GNPLIALAVAVIYAILYVL | ||||||
Transmembrane | 62-82 | Helical | ||||
Sequence: FPHLLALFAGVLLALFFLIRY |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 296-381 | Disordered | ||||
Sequence: PESIDGHRDTNTSRSCRERSSSIDAAGETVRRREGIHSSASLPLSSTEPSSPRRSQSLRSSPRLNSATNLLSSQSEHLRSSMPRKA | ||||||
Compositional bias | 334-375 | Polar residues | ||||
Sequence: SASLPLSSTEPSSPRRSQSLRSSPRLNSATNLLSSQSEHLRS | ||||||
Region | 597-627 | Disordered | ||||
Sequence: VRSTNSNQENPNSTKGSQNGQSSFGSSSERP | ||||||
Domain | 709-810 | Cyclic nucleotide-binding | ||||
Sequence: RLLSLLSPLVLHIDAALDWQQLNAGQVLYEKGDKSTDFYIVINGRLRAFTEKDGNMHVLREYGQNDSIGELDVITAVDRSDTVHAIRDSELVRIPAALFDAI | ||||||
Domain | 1074-1238 | PNPLA | ||||
Sequence: LVLGGGGARGISHIGMLQALEEFGIPIDAIGGCSIGSFVGGLYARETDLLETAGRTKQFSGRMGSMWRILSDVTYPFVSYTTGHEFNRGIYKAFYNTHIEDFWIPFFANSTNITHSRMEVHRTGYAWRYVRASMTLAGLLPPLSDNGNLLVDGGYMDNTPIQPLR | ||||||
Motif | 1078-1083 | GXGXXG | ||||
Sequence: GGGARG | ||||||
Motif | 1105-1109 | GXSXG | ||||
Sequence: GCSIG | ||||||
Motif | 1225-1227 | DGA/G | ||||
Sequence: DGG |
Sequence similarities
Belongs to the NTE family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,379
- Mass (Da)151,779
- Last updated2023-09-13 v1
- ChecksumE0EBE27688483CE2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 334-375 | Polar residues | ||||
Sequence: SASLPLSSTEPSSPRRSQSLRSSPRLNSATNLLSSQSEHLRS |