A0A9R1CFK2 · A0A9R1CFK2_9TREE

  • Protein
    Ubiquitin-like modifier-activating enzyme ATG7
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Features

Showing features for active site.

170150100150200250300350400450500550600650700
TypeIDPosition(s)Description
Active site562Glycyl thioester intermediate

GO annotations

AspectTerm
Cellular Componentphagophore assembly site
Molecular FunctionAtg12 activating enzyme activity
Molecular FunctionAtg8 activating enzyme activity
Biological Processautophagosome assembly
Biological Processautophagy of mitochondrion
Biological ProcessC-terminal protein lipidation
Biological Processcellular response to nitrogen starvation
Biological Processpiecemeal microautophagy of the nucleus
Biological Processprotein modification by small protein conjugation
Biological Processprotein transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin-like modifier-activating enzyme ATG7
  • Alternative names
    • Autophagy-related protein 7

Gene names

    • ORF names
      D1P53_004268

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MF34
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus > Cryptococcus gattii species complex

Accessions

  • Primary accession
    A0A9R1CFK2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain4-318Ubiquitin-like modifier-activating enzyme Atg7 N-terminal
Region267-303Disordered
Domain335-596THIF-type NAD/FAD binding fold

Sequence similarities

Belongs to the ATG7 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    701
  • Mass (Da)
    76,238
  • Last updated
    2023-09-13 v1
  • MD5 Checksum
    5A2FDD47D9160574B8E6B20FF15EA2A6
MPPLQFQPLASQPTPSFWAALSAHKLNHLKLDDSQLQIRAYLEPAKRILINKENAADKADVGIDGSLVVGGEAFEAEGGNLPPNAVSVSGTLKIFNTIEEFKDTSTKKRLFDDIVSQMLESFDTDQPMLNPFLLVTFADLKKYVYNYWFAFPALVSSPAWALDGEFIPVDEIEEIRNLAQSQSRNNATAFLLKGATSQLSAAPLSSCSTFYDKAQGETVTVVFHDTSSLPSNPGWTLRNVLYYLSAKHGVTSLRVVCLREGSSSIQASLSLPPPSSPPSSTTASATTPIPSKPPQAVGWERNPSGKLSPRVVDLGPMMDPTRLASQAVDLNLKLIKWRLLPSLDLDKISGTKCLLLGAGTLGCYVARILMTQGWGVRDITLADSSTVSYSNPVRQPLFTFSDCLSGGLPKAPTAAKKLAEIFPGVNAQGVVLGIPMPGHPISSSSDADASHTVEEDVAKLEELVKSHDAVFLLMDSRESRWLPTVMGKKWNKVVVNAALGFDSFLVMRHGAGRRRTQPGELEGEGMGEGEKKERKKGLGCYYCNDIVAPTDSLSDRTLDQMCTVTRPGVAPIAAAMAVELLISVLQHPLGVHAPAERPDAMDASTGTSASPLGCVPHQLRGQMYQWKTQIVEGEAFDRCTGCSDYILNEYEKNGFAFLQRVFNEKDYLEKVTGLDELYRESEAVIEGMEGLDWDSEEDGEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VHDQ01000011
EMBL· GenBank· DDBJ
KAE8539178.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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