A0A9R1CFK2 · A0A9R1CFK2_9TREE
- ProteinUbiquitin-like modifier-activating enzyme ATG7
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids701 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 562 | Glycyl thioester intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | phagophore assembly site | |
Molecular Function | Atg12 activating enzyme activity | |
Molecular Function | Atg8 activating enzyme activity | |
Biological Process | autophagosome assembly | |
Biological Process | autophagy of mitochondrion | |
Biological Process | C-terminal protein lipidation | |
Biological Process | cellular response to nitrogen starvation | |
Biological Process | piecemeal microautophagy of the nucleus | |
Biological Process | protein modification by small protein conjugation | |
Biological Process | protein transport |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameUbiquitin-like modifier-activating enzyme ATG7
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus > Cryptococcus gattii species complex
Accessions
- Primary accessionA0A9R1CFK2
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 4-318 | Ubiquitin-like modifier-activating enzyme Atg7 N-terminal | |||
Region | 267-303 | Disordered | |||
Domain | 335-596 | THIF-type NAD/FAD binding fold | |||
Sequence similarities
Belongs to the ATG7 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length701
- Mass (Da)76,238
- Last updated2023-09-13 v1
- MD5 Checksum5A2FDD47D9160574B8E6B20FF15EA2A6
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
VHDQ01000011 EMBL· GenBank· DDBJ | KAE8539178.1 EMBL· GenBank· DDBJ | Genomic DNA |