A0A9R1CD51 · A0A9R1CD51_9TREE
- ProteintRNA (guanine-N(7)-)-methyltransferase
- GeneTRM8
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids302 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.
Catalytic activity
- guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine
Pathway
tRNA modification; N7-methylguanine-tRNA biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 101 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 124-125 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: EI | ||||||
Binding site | 168-169 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: NS | ||||||
Binding site | 188 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Active site | 191 | |||||
Sequence: D | ||||||
Binding site | 275-277 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: TEE |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | tRNA (guanine(46)-N7)-methyltransferase activity | |
Molecular Function | tRNA binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA (guanine-N(7)-)-methyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Tremellomycetes > Tremellales > Cryptococcaceae > Cryptococcus > Cryptococcus gattii species complex
Accessions
- Primary accessionA0A9R1CD51
Proteomes
Subcellular Location
Interaction
Subunit
Forms a complex with TRM82.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-28 | Disordered | ||||
Sequence: MSKRTREELEMEAGPSTASPGASASPAP |
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length302
- Mass (Da)33,951
- Last updated2023-09-13 v1
- Checksum168C20F25E25032A