A0A9Q8L472 · A0A9Q8L472_9BETA

Function

function

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell Golgi apparatus
Cellular Componenthost cell plasma membrane
Cellular Componentmembrane
Cellular Componentviral envelope
Cellular Componentvirion membrane
Biological Processfusion of virus membrane with host plasma membrane
Biological Processsymbiont entry into host cell

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Envelope glycoprotein L
  • Short names
    gL

Gene names

    • Name
      U82
    • Synonyms
      gL

Organism names

  • Taxonomic identifier
  • Strain
    • NAP35 Miss Bets
  • Taxonomic lineage
    Viruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Betaherpesvirinae > Proboscivirus

Accessions

  • Primary accession
    A0A9Q8L472

Proteomes

Subcellular Location

Virion membrane
; Peripheral membrane protein
Host cell membrane
; Peripheral membrane protein
Note: gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH.

Family & Domains

Sequence

  • Sequence status
    Complete
  • Length
    301
  • Mass (Da)
    34,545
  • Last updated
    2023-09-13 v1
  • Checksum
    5EF62E73364CD0C3
MIINVNLMSGLGYSIQKMDNTIATIVIGTLRLGEYVTIFTNMFIILLLVSPNKVCALYPYVSSSCYNSTLTCLNGGNILFTGMPQYSSNYSKLIRYDYSPNIMSSGYPIDDKVYNTLSLFYKNEEDIRTFLSLRKDNNGTWEKSFIGVPELKTVHEEEKTYVFCDKAYATFFCSPYTKNCDERVNLNELPYVDSIFTEHVVELVFHGRPKVEIEVKILLYNPVTLAHKIVTIPLFTPALLDVTFNILYRTLYRNPDSHALLRTFKAFFVENVGEPYRGPRNDRFVRVWQGDGFERMGGSVL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MZ822422
EMBL· GenBank· DDBJ
UEH20658.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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