A0A9Q7T653 · A0A9Q7T653_KLEPN
- ProteinL-2-hydroxyglutarate dehydrogenase
- GenelhgO
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids422 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
Catalytic activity
- (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol
Cofactor
Pathway
Amino-acid degradation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | 2-hydroxyglutarate dehydrogenase activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor | |
Biological Process | L-lysine catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameL-2-hydroxyglutarate dehydrogenase
- EC number
- Short namesL2HG dehydrogenase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionA0A9Q7T653
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-389 | FAD dependent oxidoreductase | ||||
Sequence: DFVIIGGGIIGMSTAMQLIEIYPDARIALLEKEAGPACHQTGHNSGVIHAGVYYTPGSLKAQFCFAGNRATKAFCEQNGIRYDVCGKMLVATSPLEMERMRALWDRTAANGLQREWLSAGELREREPNITGLGGIFVPSSGIVSYREVAAAMAKNFEAKGGTIVYNAEVSALKEHVSGVVIRTRQGGEYEASTLIACSGLMADRLVKMLGVDPGFIICPFRGEYFQLAPQHNQIVNHLIYPIPDPAMPFLGVHLTRMIDGSVTVGPNAVLALKREGYRKRDISLADTLEILTSPGIRRVLQNNLRSGLGEMKNSLCRSGYLRLVQKYCPSLTLSDLRPWPAGVRAQAVSPQGKLIDDFLFVTTARSIHTCNAPSPAATSAIPIGAHI |
Sequence similarities
Belongs to the L2HGDH family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length422
- Mass (Da)45,740
- Last updated2023-09-13 v1
- Checksum40A35A4E5E7BDD25