A0A9Q5I5I7 · A0A9Q5I5I7_SANBA
- Protein2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- GeneCOQ5
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids814 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.
Catalytic activity
- a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H+ + S-adenosyl-L-homocysteine
a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol RHEA-COMP:10858 + CHEBI:59789 = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol RHEA-COMP:10859 + CHEBI:15378 + CHEBI:57856
Cofactor
Pathway
Cofactor biosynthesis; ubiquinone biosynthesis.
Protein modification; protein glycosylation.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | extrinsic component of mitochondrial inner membrane | |
Molecular Function | 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity | |
Molecular Function | glycosyltransferase activity | |
Molecular Function | UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity | |
Biological Process | dolichol-linked oligosaccharide biosynthetic process | |
Biological Process | methylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Hymenochaetales > Hymenochaetaceae > Sanghuangporus
Accessions
- Primary accessionA0A9Q5I5I7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Peripheral membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-31 | Helical | ||||
Sequence: KFALGSTVAWSAWFIARPLL | ||||||
Transmembrane | 37-59 | Helical | ||||
Sequence: LPSLYISLGFSLIAFLATLYLIP | ||||||
Transmembrane | 71-89 | Helical | ||||
Sequence: FALGSTVAWSAWFIARPLI | ||||||
Transmembrane | 101-124 | Helical | ||||
Sequence: SLGFSLIAFLATLYLIPVVGPAFI | ||||||
Transmembrane | 172-192 | Helical | ||||
Sequence: LVCASAYILSLLLFIPFPFLV | ||||||
Transmembrane | 212-231 | Helical | ||||
Sequence: LSVYLSSVLSLLMATMLGFI | ||||||
Transmembrane | 243-259 | Helical | ||||
Sequence: LPIPIIASIPLLLVYYA | ||||||
Transmembrane | 271-289 | Helical | ||||
Sequence: PLRWLLGRVINLGPLYYLY | ||||||
Transmembrane | 301-324 | Helical | ||||
Sequence: INILAGINGAEVCQAIIIALSVIL | ||||||
Transmembrane | 374-392 | Helical | ||||
Sequence: LSMYFMLPLVGVCSGFLYH | ||||||
Transmembrane | 404-422 | Helical | ||||
Sequence: TLCYVAGMAFAVVGIQAHF | ||||||
Transmembrane | 428-448 | Helical | ||||
Sequence: LFFIPQIFNFVLSCPQLFGLV |
Keywords
- Cellular component
Interaction
Subunit
Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
Structure
Family & Domains
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Belongs to the glycosyltransferase 4 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length814
- Mass (Da)90,634
- Last updated2023-09-13 v1
- Checksum6B155780BAE7D34C
Keywords
- Technical term