A0A9Q5I5I7 · A0A9Q5I5I7_SANBA

Function

function

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; ubiquinone biosynthesis.
Protein modification; protein glycosylation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site622S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site648S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site678-679S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentextrinsic component of mitochondrial inner membrane
Molecular Function2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
Molecular Functionglycosyltransferase activity
Molecular FunctionUDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
Biological Processdolichol-linked oligosaccharide biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
  • EC number
  • Alternative names
    • Ubiquinone biosynthesis methyltransferase COQ5

Gene names

    • Name
      COQ5
    • ORF names
      A7U60_g338

Organism names

Accessions

  • Primary accession
    A0A9Q5I5I7

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Peripheral membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-31Helical
Transmembrane37-59Helical
Transmembrane71-89Helical
Transmembrane101-124Helical
Transmembrane172-192Helical
Transmembrane212-231Helical
Transmembrane243-259Helical
Transmembrane271-289Helical
Transmembrane301-324Helical
Transmembrane374-392Helical
Transmembrane404-422Helical
Transmembrane428-448Helical

Keywords

Interaction

Subunit

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 4 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    814
  • Mass (Da)
    90,634
  • Last updated
    2023-09-13 v1
  • Checksum
    6B155780BAE7D34C
MGYLKPRELPSKFALGSTVAWSAWFIARPLLDPAPTLPSLYISLGFSLIAFLATLYLIPXYLKPRELPSKFALGSTVAWSAWFIARPLIDPAPTLPSLYISLGFSLIAFLATLYLIPVVGPAFIKAGLKGKDRSKVYDVDIMSRARMRVRVYTLIVAXSKVYDVDIPECQGLVCASAYILSLLLFIPFPFLVESARSRPEGLTATDFPHFQLSVYLSSVLSLLMATMLGFIDDVFDIRWRYKLPIPIIASIPLLLVYYAERGNTNVVVPIPLRWLLGRVINLGPLYYLYMAMLSTFSTNSINILAGINGAEVCQAIIIALSVILNDCLYLPWTTSFRFRLPLYLLGGKADIDFGGVWSAGMAHGSKELVERHLLSMYFMLPLVGVCSGFLYHNWYPARVFPGDTLCYVAGMAFAVVGIQAHFSKTLLLFFIPQIFNFVLSCPQLFGLVPCPRHRIPRFDGQTNLLHPSTTSFKDKPPSRLTTIVLRLLSSVGLTELTTRREDGVIIEATNLTILNVFLVRLGPMTEKQLVKTLIFTQQPQREASSTNTGNGDGKTHFGFQTVDATQKEDLVRGVFSSVAGKYDLMNDAMSFGVHRLWKDTFVEMVNPGKRGPLRCLDVAGGTGDIALRILDQARERYYDRETSVEVLDINPDMLAEGKKRFKLTMYHNTPQISFTEGNAQELNLPSDTYDLYTIAFGIRNCTSIPDVLKEAHRVLKPGGTFACLEFSRVNNPILSTIYDQYSFSILPLLGTILASDRASYQYLIESIRRFPPQEEFAQMIRDAGFATGGDHEGKGGAWTDLWGGIASVHRGVKV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LNZH02000009
EMBL· GenBank· DDBJ
OCB92246.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp