A0A9Q5HR97 · A0A9Q5HR97_SANBA

Function

function

3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, site.

114482004006008001,0001,2001,400
TypeIDPosition(s)Description
Binding site883Mg2+ (UniProtKB | ChEBI)
Site891Important for catalytic activity
Binding site892Mg2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentP-body
Molecular Function3'-5'-RNA exonuclease activity
Molecular Functionmetal ion binding
Molecular FunctionRNA binding
Biological Processpolyuridylation-dependent mRNA catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DIS3-like exonuclease 2
  • EC number

Gene names

    • ORF names
      A7U60_g8506

Organism names

Accessions

  • Primary accession
    A0A9Q5HR97

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-231Disordered
Compositional bias40-84Polar residues
Compositional bias98-139Polar residues
Compositional bias148-173Polar residues
Compositional bias211-231Polar residues
Region320-340Disordered
Region652-684Disordered
Region733-760Disordered
Compositional bias737-760Basic and acidic residues
Domain871-1209Ribonuclease II/R

Sequence similarities

Belongs to the RNR ribonuclease family. DIS3L2 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,448
  • Mass (Da)
    159,041
  • Last updated
    2023-09-13 v1
  • Checksum
    3B1F38A692EABD19
MTDEVQTPAQQQAAFKKDVSGLGGASAKPGGGRGGKRSGTPRSGSAQGSVSGKDANTRPTSRGSNKSNNANSKKAESGLQRSASGNDARRGGRGGKRGSTNTVRQQSSASKDVQAPTAKPAQTEETAGRDVQSIQRLISEMSEMRGEMRNKTSSNGVSPESATAPSSALGAHPTLTANAPVFQPGAVAFPSSKLHEPAPRHRKAASVGTNPAPPLSYSNSYSPNLGSMTEDSEVTGFEEGEISDTANFQQAHHGRSQSQSFTAPRFAALARQEQGDSMGPPGRPQLAPTFTFGARRRGTNPPVIAPAISEEDVNFQFPQQQHQQQLENLSPPQEHRRTTSTGGEITGIMAEQMALQSQIEALQQQQAALYHQQLASNQLLGSTLPGRVGGHRRVQSTLPSPMTSGFSAMGQFGTPMMGLDGQQSAPKGHGRRHSVNVLNKATGPGSSLNYGNPYASEGFDDGFTPPPAMQPAHSRQASRADTSWRMNGGVGPINANPGLTDLAQAQAQLASLQQFRAAAGGHHHKLPSFNFPNMLPNVMAANMMGLGGFNLLQQQQQQFQMALQQQNNAPQRKSLFAPYLPQASLPPLLAAGKLVVGILRVNKRNRSDAYVATEVLDADIYICGSKDRNRALEGDIVAVELLDVDEVWGTKKEKEEKKRKKEENSAYDPRSAAGRKNDKKKDDVEVEGQGLMLFEDEEVTDEVKPQFAGHVVAVVERMPGQLFSGTLGLLRPSSAATKEKQEAERREREGDRGEEQKRGPIERPKIVWFKPTDKRVPLIAIPTEQAPPDFVQNSEAYANKLFVACIKRHPISSLHPFGTLVEELGPIGDIEVETSALLKDCNFPTEEFTDNVLKCLPPTPWTIPEREHEVRTDLRKERVFTIDPDTAKDFDDAVSIKKNEDGTYNVGVHIADVSHFVKPNIALDRDARKRATSVYLVQRAVPMLPPALSEQICSLVPGQERLTFSVIFTMTEDAKVVKKRFEKTIIKSCARLTYADAQNVIDGKPLGSVPVAPEFDAVDIEHDLKILNGLAQKLRSGRSQIGTLRLDSLRLNFTLDENGLPTDTSNYERTDSHKLIEEFMLLTNMAVAQQIAHHLPEQALLRRHEEPIERRLNIFKERAARLGYTFDTSSAGAFMKSFDTIEDKNARVVLQIIAYKALHTAKYFCAGMLDIAKYNHYALNVPLYTHFTSPIRRYADIIVHRQLESIFVNANGGEPKFAMDRDSVAKVAQQCNIKKESAKLAQEQSSHLFLCVLIADLTQRYGPVIRPATVVNVLDAAFDVLVPEFGIEKRVHVDQMPIDNHVFDEHTHTLQIYWSNRDVISWLAENNDDEHLKKVKQSAEQHALKMEVSSRSVNDESALFDEDDADDEIVLGKAQPDEITKETSKQRLISQAKIRPQFEGLKTSPSGHKIQEIRELQTVPVIVTADLTKSPPVIKVYSVNPYAEEQKK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias40-84Polar residues
Compositional bias98-139Polar residues
Compositional bias148-173Polar residues
Compositional bias211-231Polar residues
Compositional bias737-760Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LNZH02000215
EMBL· GenBank· DDBJ
OCB84520.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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