A0A9Q4ZX58 · A0A9Q4ZX58_RHOHA
- ProteinDeoxyuridine 5'-triphosphate nucleotidohydrolase
- Genedut
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids180 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity
- dUTP + H2O = dUMP + diphosphate + H+
Cofactor
Pathway
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 68-70 | substrate | |||
Binding site | 81 | substrate | |||
Binding site | 85-87 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dUTP diphosphatase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | dUMP biosynthetic process | |
Biological Process | dUTP catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxyuridine 5'-triphosphate nucleotidohydrolase
- EC number
- Short namesdUTPase
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Nocardiaceae > Prescottella
Accessions
- Primary accessionA0A9Q4ZX58
Proteomes
Structure
Sequence
- Sequence statusComplete
- Length180
- Mass (Da)18,952
- Last updated2023-09-13 v1
- Checksum676EE13EC886334E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
WUXR01000001 EMBL· GenBank· DDBJ | MBM4564708.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WUYC01000011 EMBL· GenBank· DDBJ | MBM4717236.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MULT01000006 EMBL· GenBank· DDBJ | MBP0098591.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WUYZ01000002 EMBL· GenBank· DDBJ | NKS26942.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WVBC01000034 EMBL· GenBank· DDBJ | NKT81288.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WVDC01000005 EMBL· GenBank· DDBJ | NKW42299.1 EMBL· GenBank· DDBJ | Genomic DNA |