A0A9Q4ZX58 · A0A9Q4ZX58_RHOHA

Function

function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site68-70substrate
Binding site81substrate
Binding site85-87substrate

GO annotations

AspectTerm
Molecular FunctiondUTP diphosphatase activity
Molecular Functionmagnesium ion binding
Biological ProcessdUMP biosynthetic process
Biological ProcessdUTP catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • EC number
  • Short names
    dUTPase
  • Alternative names
    • dUTP pyrophosphatase

Gene names

    • Name
      dut
    • ORF names
      B0F69_18095
      , GS441_04385
      , GS505_14205
      , GS551_24235
      , GS882_24790
      , GS947_11940

Organism names

  • Taxonomic identifier
  • Strains
    • PAM2281
    • Lh_17
    • Lh_5
    • Lh_116_1
    • Lh_141_1
    • Lh_16_1
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Nocardiaceae > Prescottella

Accessions

  • Primary accession
    A0A9Q4ZX58

Proteomes

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain19-148dUTPase-like
Region160-180Disordered

Sequence similarities

Belongs to the dUTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    180
  • Mass (Da)
    18,952
  • Last updated
    2023-09-13 v1
  • Checksum
    676EE13EC886334E
MHVSDLPAVALKRLDPGIPLPRRAHEGDAGVDLCTTTDVTIEPGRRVLVGTGIAVALPIGTVGLIHPRSGLAAKTGLSVVNTPGTIDAGYRGEIKVCLINHDLETPVELRRGDRIAQLVVQKVELVDFVEVDTLDETVRGTGGYGSSGGHAILDAHNADRAVDGTEGRPHELTRQPREGA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WUXR01000001
EMBL· GenBank· DDBJ
MBM4564708.1
EMBL· GenBank· DDBJ
Genomic DNA
WUYC01000011
EMBL· GenBank· DDBJ
MBM4717236.1
EMBL· GenBank· DDBJ
Genomic DNA
MULT01000006
EMBL· GenBank· DDBJ
MBP0098591.1
EMBL· GenBank· DDBJ
Genomic DNA
WUYZ01000002
EMBL· GenBank· DDBJ
NKS26942.1
EMBL· GenBank· DDBJ
Genomic DNA
WVBC01000034
EMBL· GenBank· DDBJ
NKT81288.1
EMBL· GenBank· DDBJ
Genomic DNA
WVDC01000005
EMBL· GenBank· DDBJ
NKW42299.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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