A0A9Q4ZT49 · A0A9Q4ZT49_RHOHA

Function

function

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site103-105substrate
Binding site127-130substrate; in site B
Binding site137-139substrate
Binding site185substrate
Active site186Proton donor/acceptor
Active site317
Binding site318substrate
Binding site323-325substrate
Site330Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionfumarate hydratase activity
Biological Processfumarate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fumarate hydratase class II
  • EC number
  • Short names
    Fumarase C
  • Alternative names
    • Aerobic fumarase
    • Iron-independent fumarase

Gene names

    • Name
      aspA
    • Synonyms
      fumC
    • ORF names
      B0F69_05780
      , GS882_23525
      , GS947_02075

Organism names

Accessions

  • Primary accession
    A0A9Q4ZT49

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-341Fumarate lyase N-terminal
Domain407-464Fumarase C C-terminal

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    468
  • Mass (Da)
    49,505
  • Last updated
    2023-09-13 v1
  • Checksum
    1C94D4C4CB207A93
MSDSSDPQFRIEHDTMGEVRVPVDALWRAQTQRAVENFPISGRGLERAQIRAMGLLKAACAQVNKDLGLLDPDKADAIIAAANEIAEGRHDDQFPIDVFQTGSGTSSNMNANEVIASLAAKAGVTVHPNDDVNMSQSSNDTFPTATHVAATEAAVKDLVPALDHLRLALFDKAAQWKTVVKSGRTHLMDAVPVTLGQEFGGYAHQIEAGIERVLATLPRLGELPIGGTAVGTGLNAPDGFGPRVVTELVRTTGLDALSPARNSFEAQAARDGLVEASGALRTVAVSLTKIANDVRWMGSGPLTGLGEIRLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVVGNDAAVAWGGAAGAFELNVYIPVMARNLLESFRLLANVSRLFADRCIAGLEANEEHLRTLAESSPSIVTPLNSAIGYEEAAAVAKQALKEKKTIRQTVIDRGLIGDGLTEAELDRRLDVLAMTRADDE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MULT01000002
EMBL· GenBank· DDBJ
MBP0096181.1
EMBL· GenBank· DDBJ
Genomic DNA
WVBC01000034
EMBL· GenBank· DDBJ
NKT81046.1
EMBL· GenBank· DDBJ
Genomic DNA
WVDC01000001
EMBL· GenBank· DDBJ
NKW40438.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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