A0A9Q3WJB4 · A0A9Q3WJB4_9RHOB
- ProteinPenicillin-binding protein 1A
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids828 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+
[GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate RHEA-COMP:9602 + CHEBI:60033 = [GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate RHEA-COMP:9603 + CHEBI:58405 + CHEBI:15378
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | carboxypeptidase activity | |
Molecular Function | penicillin binding | |
Molecular Function | peptidoglycan glycosyltransferase activity | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | proteolysis | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePenicillin-binding protein 1A
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Roseobacteraceae > Ruegeria
Accessions
- Primary accessionA0A9Q3WJB4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-34 | Helical | ||||
Sequence: IFSLVTLGVFMVALTIGGVFWMY |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 60-235 | Glycosyl transferase family 51 | ||||
Sequence: GQLIDEFAKERRLFTPADEIPDLVKQAFISAEDKNFYTHQGYDIRGIAAAGVEAIRSRGSNVRGASTITQQVMKNFLLSGDRRAERKIKEIILAARLEQTLNKEQILELYMNEIFLGQNSYGVTAAAQTYFNKTLAELAPHEAATLAAMPKAPSDYHPVREYQRLLDRRNYVLREM | ||||||
Domain | 329-431 | Penicillin-binding protein OB-like | ||||
Sequence: WHGTGKTIEPAKLGDEDVWRAELAATEVPRDVDLGGRWHPAVVLGVGDQELTVGIEDGPAKGRVPRADIKWMKGSFKDNFALGDVVLVRKADEDWSLRQVPEV | ||||||
Domain | 433-689 | Penicillin-binding protein transpeptidase | ||||
Sequence: GGFMAMDVNTGRVLAMQGGFSYQDSVFNRATQAQRQPGSSFKPFVYAAALDSGYSPATIVVDAPIEVNTPQGLWRPKNASNKFYGPTPLRTGIERSRNLMTIRLAQEVSMPVVAGYAERFGVYDHMGPFLANALGSEETTLYKMVAAYAMFANGGERVEPTLVDRIQDRFGKTIYRHDRRDCVDCLSDRLDPDQAPRIVTNRERVMDAITAYQLTSMMRGVVERGTASGAVNLPVPTAGKTGTTNDAKDVWFIGFTS |
Sequence similarities
In the C-terminal section; belongs to the transpeptidase family.
In the N-terminal section; belongs to the glycosyltransferase 51 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length828
- Mass (Da)91,577
- Last updated2023-09-13 v1
- Checksum5B5CF20EC0D71352