A0A9Q0LPP8 · A0A9Q0LPP8_ANAIG

Function

function

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Cellular Componentnucleus
Molecular Functionaspartic endopeptidase activity, intramembrane cleaving
Biological ProcessNotch signaling pathway
Biological Processprotein processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Presenilin
  • EC number

Gene names

    • ORF names
      M0811_07709

Organism names

Accessions

  • Primary accession
    A0A9Q0LPP8

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Golgi apparatus membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane72-93Helical
Transmembrane130-149Helical
Transmembrane156-178Helical
Transmembrane190-210Helical
Transmembrane215-233Helical
Transmembrane239-256Helical
Transmembrane374-398Helical
Transmembrane404-423Helical

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for coiled coil, region.

TypeIDPosition(s)Description
Coiled coil8-39
Region296-316Disordered

Domain

The PAL motif is required for normal active site conformation.

Sequence similarities

Belongs to the peptidase A22A family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    437
  • Mass (Da)
    50,894
  • Last updated
    2023-09-13 v1
  • Checksum
    2A3EC1FA42F9A6CC
MTNQNQNQNQNQNQNINLNQNLNENQNQNQNQNQNQNQNINSDEILFRQSEYLMRKFQPTLFIELISKKLKWVLIPVSITMILVAFFIESIYISGENSNGSPKQGFNSIPVFKSNLNNSTNNFNLNDWELALFIVGLIFATTIIFLILFKLKCYKILLYWLILSTFGMLLFFSASSFLDILQIFNLGIDWISFVMLIYNFSVVGILTMFWHGPKWISQGYLIIFSVLLASILAKLPKTTNWILLILISFYDIFAVLSSKGPLKMLIDEAVKADQQLPFLIYSSAAWIFSTNFDKENNPKKKEKENEKEKEKESISEDENEELRRLIVRPINEFDLKNENNQEFIQNFSESRIKLGLGDFIFYSLLMSLACFSSYLTVFITFIGILTGLTITLFFLVVYEKALPALPISIFLGIVFYFLTDLILNQFKEKYEQSWIFF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAPDFW010000067
EMBL· GenBank· DDBJ
KAJ5075005.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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