A0A9Q0L872 · A0A9Q0L872_ANAIG
- ProteinO-phosphoseryl-tRNA(Sec) selenium transferase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids550 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Catalytic activity
- O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H2O = L-selenocysteinyl-tRNA(Sec) + 2 phosphate
Cofactor
Pathway
Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2.
Features
Showing features for site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 74 | May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate | ||||
Sequence: E | ||||||
Binding site | 75 | pyridoxal 5'-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 97 | substrate | ||||
Sequence: R | ||||||
Binding site | 98 | substrate | ||||
Sequence: S | ||||||
Binding site | 105 | substrate | ||||
Sequence: Q | ||||||
Binding site | 272 | tRNA (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 314 | substrate | ||||
Sequence: R | ||||||
Binding site | 405 | tRNA (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 470 | tRNA (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | O-phosphoseryl-tRNA(Sec) selenium transferase activity | |
Molecular Function | tRNA binding | |
Biological Process | conversion of seryl-tRNAsec to selenocys-tRNAsec | |
Biological Process | selenocysteine incorporation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameO-phosphoseryl-tRNA(Sec) selenium transferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metamonada > Anaeramoebidae > Anaeramoeba
Accessions
- Primary accessionA0A9Q0L872
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 285 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Structure
Family & Domains
Features
Showing features for coiled coil, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 189-216 | |||||
Sequence: IVEQLLENDELVTDLEEIENQIQKCGSE | ||||||
Compositional bias | 507-524 | Polar residues | ||||
Sequence: NSNQNQNQNQNHQLEDNQ | ||||||
Region | 507-527 | Disordered | ||||
Sequence: NSNQNQNQNQNHQLEDNQLEN |
Sequence similarities
Belongs to the SepSecS family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length550
- Mass (Da)61,947
- Last updated2023-09-13 v1
- Checksum93EDA021A9D39B1B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 507-524 | Polar residues | ||||
Sequence: NSNQNQNQNQNHQLEDNQ |
Keywords
- Technical term