A0A9P9LEN4 · A0A9P9LEN4_9HELO
- ProteinHistone-lysine N-methyltransferase, H3 lysine-4 specific
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1264 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.
Catalytic activity
- L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = N6,N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H+
- N6,N6-dimethyl-L-lysyl4-[histone H3] + S-adenosyl-L-methionine = N6,N6,N6-trimethyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine + H+
- N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-methionine = N6,N6-dimethyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine + H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | Set1C/COMPASS complex | |
Molecular Function | histone H3K4 methyltransferase activity | |
Biological Process | methylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone-lysine N-methyltransferase, H3 lysine-4 specific
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Helotiales > Helotiales incertae sedis > Rhexocercosporidium
Accessions
- Primary accessionA0A9P9LEN4
Proteomes
Subcellular Location
Interaction
Subunit
Component of the COMPASS (Set1C) complex.
Component of the Set1C/COMPASS complex.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 17-46 | Disordered | |||
Compositional bias | 19-33 | Basic and acidic residues | |||
Compositional bias | 114-171 | Polar residues | |||
Region | 114-184 | Disordered | |||
Region | 542-570 | Disordered | |||
Compositional bias | 551-570 | Basic and acidic residues | |||
Region | 661-688 | Disordered | |||
Region | 736-767 | Disordered | |||
Domain | 1122-1239 | SET | |||
Domain | 1248-1264 | Post-SET | |||
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,264
- Mass (Da)140,734
- Last updated2023-09-13 v1
- ChecksumFB3613860222582D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 19-33 | Basic and acidic residues | |||
Compositional bias | 114-171 | Polar residues | |||
Compositional bias | 551-570 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAGTJL010000030 EMBL· GenBank· DDBJ | KAH7306080.1 EMBL· GenBank· DDBJ | Genomic DNA |