A0A9P8LCC9 · A0A9P8LCC9_9PEZI

  • Protein
    ATP-dependent RNA helicase eIF4A
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionATP binding
Molecular Functionhydrolase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular Functiontranslation initiation factor activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent RNA helicase eIF4A
  • EC number
  • Alternative names
    • Eukaryotic initiation factor 4A
    • Translation initiation factor 1

Gene names

    • ORF names
      GP486_003898

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CAQ_001_2017
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Geoglossomycetes > Geoglossales > Geoglossaceae > Trichoglossum

Accessions

  • Primary accession
    A0A9P8LCC9

Proteomes

Interaction

Subunit

Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.

Family & Domains

Features

Showing features for domain, motif, coiled coil, region.

Type
IDPosition(s)Description
Domain24-52DEAD-box RNA helicase Q
Motif24-52Q motif
Domain55-225Helicase ATP-binding
Domain236-397Helicase C-terminal
Coiled coil519-546
Region627-673Disordered

Sequence similarities

Belongs to the DEAD box helicase family. eIF4A subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    673
  • Mass (Da)
    75,352
  • Last updated
    2023-09-13 v1
  • Checksum
    C3FFB7C14CA484D1
MATDKGLEEITEGQIESNYDETIDSFDSMNLKPELLRGVYAYGFERPSAIQQRAIMPVIKGHDVIAQAQSGTGKTATFSISVLQKLDPNLKQCQALILAPTRELAQQIQKVVVAIGDFMNVECHACIGGTSVRDDMKALQEGPQVVVGTPGRVHDMIQRRFLKTDSMKMFVLDEADEMLSRGFTEQIYDIFQLLPQATQVVLLSATMPQDVLEVTTKFMRDPVRILVKKAELTLEGIKQFFIAVEKEDWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTDKLTARDFTVSAMHGDMDQAQRDMIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTAEDVRMMREIEQFYSTQIEEMPMNVAALVFPSKETPNPNTIATIHPAAGSQSRIITALCGKMATSSRAPKPVTLNLSPVDLLWGQKLRLENADLQKKFRGFETSLITLRERIEELETTTTRRIGILERDNADLRGEVAGLVRKDLRLIAEMEKSTSKIEQLGSENRTLKEQVQRTEQAAHCTSKSQDQTKESLALVSRRLCELQLKMEELRKELADIRGNRKVTVSAASIPGGYAGTGKEECVLPSSTLEKLMQEEKNFGLARSSTTPGRRKGILSSAAEESAQEEDPRFARQAGIRGKRSKRRG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAGHQM010000564
EMBL· GenBank· DDBJ
KAH0559582.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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