A0A9P7Y9M6 · A0A9P7Y9M6_9HELO

Function

function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site116-121ATP (UniProtKB | ChEBI)
Binding site142a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site164-166a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site197-200a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site204a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site235ATP (UniProtKB | ChEBI)
Binding site241a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site252a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site280ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Function(d)CMP kinase activity
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological ProcessCDP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridylate kinase
  • EC number
  • Short names
    UK
  • Alternative names
    • ATP:UMP phosphotransferase
    • Deoxycytidylate kinase
      (CK
      ; dCMP kinase
      )
    • Uridine monophosphate kinase
      (UMP kinase
      ; UMPK
      )

Gene names

    • ORF names
      BJ875DRAFT_182737

Organism names

  • Taxonomic identifier
  • Strain
    • TRa018bII
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Helotiales > Helotiales incertae sedis > Amylocarpus

Accessions

  • Primary accession
    A0A9P7Y9M6

Proteomes

Subcellular Location

Cytoplasm
Nucleus
Note: Predominantly cytoplasmic.

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region19-54Disordered
Region136-166NMPbind
Region234-244LID

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    301
  • Mass (Da)
    33,746
  • Last updated
    2023-09-13 v1
  • MD5 Checksum
    30A04EA110D00B8B4D9C6032A4AB8FE7
MAHPTTRIFTRRVCQQFSPFRRPSSPIPRHLRAPASRRSYAASGEKGPNPGRPGQSPFKVWPFIAITLAGSGAYVLMVRSRQDMDPKTGQIAAPKKDTPTFSPSKVTVLFVLGGPGAGKGTQCANLVRDYHFTHLSAGDLLRAEQDREGSEFGNLIKEYIRDGKIVPMEVTVQLLENAMAEQVQKDPAAKGKFLIDGFPRKMDQAIKFEETVCPSKFVLFFDCPEEEMQRRLLERGKTSGRSDDNAESIKKRFKTFLETSMPVVDYFEGQGRVVKVVATKTPDEVYNETRGRLEQRLGKQF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MU251741
EMBL· GenBank· DDBJ
KAG9229674.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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