A0A9P7Y9C4 · A0A9P7Y9C4_9HELO
- ProteinInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1583 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Catalytic activity
- 1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoskeleton | |
Cellular Component | cytosol | |
Molecular Function | 5-diphosphoinositol pentakisphosphate 1-kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | inositol hexakisphosphate kinase activity | |
Biological Process | inositol metabolic process | |
Biological Process | inositol phosphate biosynthetic process | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Helotiales > Helotiales incertae sedis > Amylocarpus
Accessions
- Primary accessionA0A9P7Y9C4
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-323 | Disordered | |||
Compositional bias | 7-21 | Polar residues | |||
Compositional bias | 29-79 | Polar residues | |||
Compositional bias | 109-134 | Polar residues | |||
Compositional bias | 184-266 | Polar residues | |||
Compositional bias | 303-319 | Polar residues | |||
Domain | 340-427 | VIP1 N-terminal | |||
Domain | 564-656 | ATP-grasp fold RimK-type | |||
Region | 684-708 | Disordered | |||
Compositional bias | 692-708 | Polar residues | |||
Region | 727-774 | Disordered | |||
Compositional bias | 750-768 | Polar residues | |||
Compositional bias | 949-968 | Basic and acidic residues | |||
Region | 949-972 | Disordered | |||
Coiled coil | 1068-1095 | ||||
Compositional bias | 1250-1268 | Basic and acidic residues | |||
Region | 1250-1290 | Disordered | |||
Compositional bias | 1531-1545 | Basic and acidic residues | |||
Region | 1531-1583 | Disordered | |||
Sequence similarities
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,583
- Mass (Da)173,296
- Last updated2023-09-13 v1
- MD5 Checksum26BE9574770D686A7370D944C0BAB93E
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 7-21 | Polar residues | |||
Compositional bias | 29-79 | Polar residues | |||
Compositional bias | 109-134 | Polar residues | |||
Compositional bias | 184-266 | Polar residues | |||
Compositional bias | 303-319 | Polar residues | |||
Compositional bias | 692-708 | Polar residues | |||
Compositional bias | 750-768 | Polar residues | |||
Compositional bias | 949-968 | Basic and acidic residues | |||
Compositional bias | 1250-1268 | Basic and acidic residues | |||
Compositional bias | 1531-1545 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MU251796 EMBL· GenBank· DDBJ | KAG9229252.1 EMBL· GenBank· DDBJ | Genomic DNA |