A0A9P7HGT7 · A0A9P7HGT7_9HYPO

  • Protein
    NADPH--cytochrome P450 reductase
  • Gene
    cprA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per monomer.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site228-233FMN (UniProtKB | ChEBI)
Binding site279-282FMN (UniProtKB | ChEBI)
Binding site320-329FMN (UniProtKB | ChEBI)
Binding site355FMN (UniProtKB | ChEBI)
Binding site448NADP+ (UniProtKB | ChEBI)
Binding site604-607FAD (UniProtKB | ChEBI)
Binding site622-624FAD (UniProtKB | ChEBI)
Binding site639-642FAD (UniProtKB | ChEBI)
Binding site701NADP+ (UniProtKB | ChEBI)
Binding site763-764NADP+ (UniProtKB | ChEBI)
Binding site769-773NADP+ (UniProtKB | ChEBI)
Binding site805NADP+ (UniProtKB | ChEBI)
Binding site843FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial outer membrane
Cellular Componentplasma membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity
Biological Processergosterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH--cytochrome P450 reductase
  • EC number
  • Short names
    CPR
    ; P450R

Gene names

    • Name
      cprA
    • ORF names
      H9Q72_012814

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • IMI 127659i
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium fujikuroi species complex

Accessions

  • Primary accession
    A0A9P7HGT7

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein
Mitochondrion outer membrane
; Single-pass membrane protein
Cell membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane161-181Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain222-372Flavodoxin-like
Domain429-687FAD-binding FR-type

Sequence similarities

Belongs to the NADPH--cytochrome P450 reductase family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    843
  • Mass (Da)
    93,830
  • Last updated
    2023-09-13 v1
  • Checksum
    3A52D041D78D1676
MATSTTRVANCSRALCAMLDEWQIMNRLFGVLDMWKASRDLITRISTERSAGKPIKKLDIGIQASQILCLTSFHVSEAIGFLSSKGILKRSAESEERLTFLAIRSWAAFTMIEIGRLSLEWMNTMRDKEKLATKTWKAKWKSDMLQNLAWASVATHWKSPIINSTDLIVLLSLLLGAIAYLSNGKLRKLFFPKPTTSEESTASKEDSLRSISHICNNTGKNCIIFYGSQTGTAENYAQKLAREASSRYGLDPMVADLEEYDYNDLSELSEQVVLMFVLATYGEGEPTDNAQDFYTYITGGEDGEQPDVDLQNVKYVAFGLGNSTYEHYNAMVRRVSKALDGLGAKNLAGVGEADDAAGTTEEDFLAWKQDMWPKLVQEFGLKERDVAYESTFGVLERDDLDASSPGVFLGEANAKHLDTSSANRQFSNTNPYIASITESREVFTSKDRNCIHMEIDLGDSGLSYETGDHVAIWPTNSEDQVTQLLNILGLSEKKDTVISIVSREATAKSPVPTPTTYATALRYYLEIAGPVSREFINVIAAFAPTDAAKAEAAKLGSDKVYFHEKISQKCLSLARVLSTLSGDQPWTKLPFSAIVEGLSKLQLRYYSISSSSHVQPSTVSITAAVESAEIQGRPDVFKGVATNYLLSLKQAQNQESQPRKYQLNGPREKYTGFKAPIHLRKSNFKLPKDSSRPVIMIGPGTGVAPFRGFVQERAALKKEGKSVAKSLLLFGCRRRDEDYLYESEWREHKNTLGDSFDIHVAFSRETKQKVYVQHLIKTHAEEVMDLIDNGAIVYVCGDAKHMARDVNSTLISIWADQRSISIESAAEKVKGLRDSARYQEDIW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JADFTT010000719
EMBL· GenBank· DDBJ
KAG5759057.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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