A0A9P7DMY3 · A0A9P7DMY3_9AGAM
- ProteinAlpha-1,3/1,6-mannosyltransferase ALG2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids478 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Mannosylates Man2GlcNAc2-dolichol diphosphate and Man1GlcNAc2-dolichol diphosphate to form Man3GlcNAc2-dolichol diphosphate.
Catalytic activity
- an alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H+This reaction proceeds in the forward direction.
an α-D-Man-(1→3)-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol RHEA-COMP:19513 + CHEBI:57527 = an α-D-Man-(1→3)-[α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol RHEA-COMP:19515 + CHEBI:58189 + CHEBI:15378 - a beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H+This reaction proceeds in the forward direction.
Pathway
Protein modification; protein glycosylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | alpha-1,3-mannosyltransferase activity | |
Molecular Function | GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity | |
Molecular Function | GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity | |
Biological Process | oligosaccharide-lipid intermediate biosynthetic process | |
Biological Process | protein glycosylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-1,3/1,6-mannosyltransferase ALG2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Boletales > Suillineae > Suillaceae > Suillus
Accessions
- Primary accessionA0A9P7DMY3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 456-474 | Helical | ||||
Sequence: WLMMSAVLGLLVVLIFRYG |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 19-206 | Glycosyltransferase subfamily 4-like N-terminal | ||||
Sequence: IGGAERLVVDAALGLQSLGHSVDIYTSHHDKHHCFDETRDGTLSVHHVIPPLPRSIQGKFHIMFAHARQLHLTMHLMCTSAHQYDVFFVDQLSTCIPFLRMFCGKRVVFYCHFPDKLLANGAYVEDQRGKSVSILKYIYRFPMDWLEEATTTQADLILANSKFTARVTKSHFSSLRHQLKVVYPGINI | ||||||
Domain | 220-421 | Glycosyl transferase family 1 | ||||
Sequence: ILQVASQRRTLLSLNRFEMKKNAALAIEAFAILRNKDPSTSNVRLVLAGGYDPRLEDNMRTLKSLIELAQFNDLTYNVITLSQSRVSVPSFQKMTLNEPDILFLLNFTTAQRSCLLQAQSTLALLYTPANEHFGIGPVEGMICGLPVLACDSGGPTESIVDQPPDQRTGWLYRPQPSVWAQALKEICNLSETDRKALSQRAQ |
Sequence similarities
Belongs to the glycosyltransferase group 1 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length478
- Mass (Da)53,494
- Last updated2023-09-13 v1
- ChecksumD0CD85CE7DDE9B23
Keywords
- Technical term