A0A9P7D1C0 · A0A9P7D1C0_9AGAM

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      EV702DRAFT_1199280

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DOB743
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Boletales > Suillineae > Suillaceae > Suillus

Accessions

  • Primary accession
    A0A9P7D1C0

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane85-107Helical
Transmembrane114-133Helical
Transmembrane139-158Helical
Transmembrane170-190Helical
Transmembrane210-232Helical
Transmembrane272-292Helical
Transmembrane312-332Helical
Transmembrane339-356Helical
Transmembrane362-384Helical
Transmembrane438-460Helical
Transmembrane522-543Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain49-457Major facilitator superfamily (MFS) profile

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    558
  • Mass (Da)
    61,345
  • Last updated
    2023-09-13 v1
  • MD5 Checksum
    8E5861C7AAE3BBBCF567D0C068C05988
MSTASIRFINAVQVAPADVKSKDEHQSSISVPSYSSVKPKLPLRWQVAIIVLTCMCTFGHHWSDNLITTLKTTIKHELKINNSEFATLVSATNLVNTFLCIAVGFVIDKFGGPLLSAILAAFCLAGFAVEAGATTNGLNSYHVLMVGKIITAVGGGSIDNAQHKIFTTYFAPGNGFALSIGIIWSMANVAQYVGQSTANVMSKNLGSYSWPLWIGAIIGLFSFLCAICVFILDKYLRSHYEVVDYSKRFDQPSTGSVKVRTFHWSVLRQMPFTLWFVVLFATFQTAGVESFVSVSTQFAQQRLEKGAVVGGWVSSFYLLLPIGLTPFMGMFIDAYGRRVTILFLSGCMFLISMLLLQFSQTVPTFICAYVFYALAQTITSAPQVEIVRSIIPDPRYYATAFAIKKSIVQGSTIIIVTATGKLQDLSPTDSLESTVTVWLVYAFVSVLISGVLLGACYTSLGQRYLPAARLSQVRPEHVEREVERLWELRRHKVTEEGKRDESVTPKQKEVVLKSPVPSSVSLYARWVALGAGFTIVLIAWVIFGVGIEWGDHASATRE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABBWD010000033
EMBL· GenBank· DDBJ
KAG1775533.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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