A0A9P6ZGP9 · A0A9P6ZGP9_9AGAM

  • Protein
    Translation initiation factor eIF2B subunit gamma
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componenteukaryotic translation initiation factor 2B complex
Cellular Componentguanyl-nucleotide exchange factor complex
Molecular Functionguanyl-nucleotide exchange factor activity
Molecular Functiontranslation initiation factor activity
Biological Processcytoplasmic translational initiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Translation initiation factor eIF2B subunit gamma
  • Alternative names
    • eIF2B GDP-GTP exchange factor subunit gamma

Gene names

    • ORF names
      EV702DRAFT_1212402

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DOB743
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Boletales > Suillineae > Suillaceae > Suillus

Accessions

  • Primary accession
    A0A9P6ZGP9

Proteomes

Interaction

Subunit

Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain18-150Nucleotidyl transferase
Region405-442Disordered
Compositional bias420-442Acidic residues

Sequence similarities

Belongs to the eIF-2B gamma/epsilon subunits family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    442
  • Mass (Da)
    49,323
  • Last updated
    2023-09-13 v1
  • MD5 Checksum
    94C2ACD5324640E6476F6568CC32A510
MMNFDVTAVEVVTREFVAVILAGFGNELHPLTGEHGDVPCPKALLPISNKPMLDYPLSWVEQSGIKDVLLICPSSHRPAISHYIHSQSSSASFSSVHIDLQTFDESQELSAGTCSVLRHFANRIKEDFILIPCDFIPPPSLPLSKLLNKFRTDTMSDGSIVTSCWYEHKLDKQTTPDEWGSPAKPTPIVWDHLSGTLLYVDSPHEAVKNSDELELRMTLLSRYPQAKLSSRLLDSHVYVCKRAMLDLLAQKTRFDSLREDFFPWLCKLQYQSTKQEKYATSIRIGVIIHRADDGFAIRVNNLPAYLEANRHIITENEIHQFVADTSIGDFTRVEEKSTIKKSTIGKHCVIGKMVKIVGCVLLDHCVISDGTKLDGCILGNSTTVGSKAELTRCVTQAGYEVKDNESVQHEKLDISDWAAQPEDSEGDIEDSTGEEGSDEDED

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias420-442Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABBWD010000106
EMBL· GenBank· DDBJ
KAG1765494.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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