A0A9P6R4K6 · A0A9P6R4K6_9FUNG

  • Protein
    ATP-dependent DNA helicase II subunit 2
  • Gene
    KU80
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome, telomeric region
Cellular ComponentKu70:Ku80 complex
Molecular FunctionATP binding
Molecular Functiondamaged DNA binding
Molecular Functiondouble-stranded DNA binding
Molecular Functionhelicase activity
Molecular Functionhydrolase activity
Molecular Functiontelomeric DNA binding
Biological ProcessDNA recombination
Biological Processdouble-strand break repair via nonhomologous end joining
Biological Processtelomere maintenance

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent DNA helicase II subunit 2
  • EC number
  • Alternative names
    • ATP-dependent DNA helicase II subunit Ku80

Gene names

    • Name
      KU80
    • ORF names
      BGZ99_000675

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • REB-010B
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mortierellomycotina > Mortierellomycetes > Mortierellales > Mortierellaceae > Dissophora

Accessions

  • Primary accession
    A0A9P6R4K6

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region140-173Disordered
Compositional bias148-162Basic and acidic residues
Domain246-278C2H2-type
Domain279-308C2H2-type
Region342-508Disordered
Compositional bias414-438Polar residues
Compositional bias463-477Basic and acidic residues
Compositional bias492-508Basic and acidic residues
Region544-566Disordered
Region1470-1494Disordered
Compositional bias1478-1494Acidic residues

Sequence similarities

Belongs to the ku80 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,494
  • Mass (Da)
    165,095
  • Last updated
    2023-09-13 v1
  • Checksum
    6A023F8383A0453E
TSASTSTFDAMKDTRERDMNGNTAQEVTSIMDLQSMLARFWDAHSKQFKEIESSLTGQLSTLIQKNGFLCQKIENLQRSNTDLEYKFSITTSELERARKEYAELHAKYELRDANYKDLKAVCYQLDAQLNLRNGSTSEESLMSRLEQMGSESKKRRLSVDMADVESDQGSTSFDEDVAGDEFMAASSARAIGPLESSQMQDASPKETPSQGKWTCLWRSCNQVFGALDWLVSHVEESHIGLGKSQYMCEWENCVVKKKPFHKHHQVIRHMRTHTGEKPFICNVDGCGKKFARSDSLLEHSRKHIGTPVDYYRIMEFSSLREHDAKHLDGLLLELDPIQEHQQSSNFDSIARDSASGASRDGSRPDRMAPDQALSPKEGKQASSDQAPLEKRAQADGAESRPSAPGAGQALASAPGALPTSNTTAMSASSLSTQQWPERPPHPGQFAGRMGPSYGAVSKQNMSHHHRPSSDLTTLHRTRGHAHTGSLGFSKMDIHDPPRHRPYGHSHSRSMDYSRVDLMSQPHRSREFGHSQTPSLDYSRADMFQSGHRGHSHTPSLEMPPTPIQQMHRSDDRMQGLMPHPVILERQQQLAQQLRQSFSQTMQPAKDSMATGQRTENTRDLFDSIVEGSTPKLQQSAPPSEETINPAAEPGHSLMDEDSTFKEATIYVLDVGPTMKIKREGARMSRHDETKEVLLKLLANKVHMNRKTVYVSVILVGSNITNNDLASEDENGADYQFVDVLQPLGIATLELMKGVQDDVKLGETMGDCMDGLIVAMDMMTKFCKKLKYEKKIYILTDACGEINSDGLETIISNLAGDNIQLNVIGTEFDGDDEEPKQKSPIQAQNEELFKKLSEASSGNVFSVDEALDITAQFYSKKVKPTAVYRGTLDLGDPERHPESSLSIPVHMYPSTMVVKLPTAKKYSMLSDSAPTDELPDGQTGMVNLSRTYKLKVTADMADGDMDVDTEVPADALEKAYMYGKTIVPIRAVDLDAYKLRTAKSLTILGFFASSTFRREWLMNNIYSVFPSPGDGKAEVEISGLLFALFEKNSYALCRYVRVDDAEPKLGVLWPEITAEYKCFYFGQVAFSEDIRRYLFASLDDIQTASGKKLEKHRLLATPESIDACKEFISAMDLMTANGGEEYLKPEETFNPSFQRQMQLVEFRALNPTKEFPPMATSLISQLMPKPDLLAAAEHLSDNLIRLWDIKKNEQPLKGKRGYAASLEENDKDGMAAISGGAGMDGSSGSLFDGLTGNKRHKSESVFGTATTSSVMGANGGGTVAGTGSVFGSTTGDLAASGIIPFELSAIREVGTSDPVKDFQAMVKIATIQSQQGVRPAGAGFVTVSLAVDQMKAMILKLISTSFGDQLYEKALDCLQSLRGFLSNTETADLVGMHSEEERKETIKNRVETWNTFIREVKQMCLNTSVSPLRKDFWDLIAKQKQGLGLLTAKEVPAGAHGVSEQDAEQFMLVTSDDTSAAAAEEPEAPEEDELLALMD

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias148-162Basic and acidic residues
Compositional bias414-438Polar residues
Compositional bias463-477Basic and acidic residues
Compositional bias492-508Basic and acidic residues
Compositional bias1478-1494Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAAIP010001134
EMBL· GenBank· DDBJ
KAG0310090.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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