A0A9P6PMX1 · A0A9P6PMX1_9FUNG

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      BG011_008499

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • KOD948
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mortierellomycotina > Mortierellomycetes > Mortierellales > Mortierellaceae > Mortierella

Accessions

  • Primary accession
    A0A9P6PMX1

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane68-85Helical
Transmembrane105-128Helical
Transmembrane140-158Helical
Transmembrane164-186Helical
Transmembrane198-219Helical
Transmembrane231-255Helical
Transmembrane367-386Helical
Transmembrane406-428Helical
Transmembrane435-454Helical
Transmembrane460-482Helical
Transmembrane494-516Helical
Transmembrane522-544Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region600-619Disordered
Region627-686Disordered
Compositional bias632-656Polar residues
Region796-842Disordered

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    842
  • Mass (Da)
    92,648
  • Last updated
    2023-09-13 v1
  • Checksum
    A2659CBAF502B908
MAHKKVRSLDSTLDDNDDAAESVSQLESFPPLFVARPNVMNSPSLRFVEPMDAADSMHSDKGQVHRRWYILALSCMLLFGNYFAYDNPAALNTQLQKYLEMPYNDYQYLLSTLYSVYSLPNTVLPFLFGSLVDRLGPRKVLLVLSGCACLGQTIFSIGVQSRQIWMMLVGRAIFGIGGESCGVAQASITTMHFRGHELAFALGLNLCIARFGSVINTLVTPWAEQQWDVPTAIWIGTLSCVISFLAAVLLVIMISQPSSVALTSMATSKQYSESTPLLQSDYGTFTGTHVTASMDEDDITSSPAIIRHLLRREVSVSDSIHSARFTPGHVKAGSRPTLHIVTDQSPYKKHGDSWWARWRDDLRVFPLSFWLICVLIVLLYGTVVPFNNIASDFLQSKWYPGNPRKAAAMMGIPDTLGAVLVPGFGLLVDRYGRRASTLIWSALIMMIVHMTLGFTSLNPIFAFTLLGIAYSMYGVALWPSIACVVTSELHLGKAYGISSSFLNISLTVVPPIVATIRVAGESFIPVEMFFVFMGLCGIAVGFMLKGIDRRDGGTLEEPEISVDVPVIVPQTSFSAVASSTASPVVSQSRARFAKRQRPQLDIFQSPGLRPQRSVSESGQGILKRWQDEEQGGDTESGTLGSNQGGSHDTIATHEGSGGYSPTAGIVQDHHGDMSMPPLADRPSRRRKWYSRPLLQRTLTRMESPLLQQYANSPLCGSFSSPSISTTMEEFPWNMEEGAMPVVEGYSVSQHPILYNPLRGSSGSFRISRNARPVTFGDGEEGLLYINDQIVDLGDGDEHNSLMRDSEEDDYNIGDENDDRTEDATLTNSNNGDVEDRRQEIDP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias632-656Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAAJA010000702
EMBL· GenBank· DDBJ
KAG0250307.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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