A0A9P6FBY3 · A0A9P6FBY3_9FUNG

  • Protein
    Enolase-phosphatase E1
  • Gene
    ENOPH1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site157Mg2+ (UniProtKB | ChEBI)
Binding site159Mg2+ (UniProtKB | ChEBI)
Binding site294-295substrate
Binding site328substrate
Binding site353Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Function2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity
Molecular Function2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity
Molecular Functionacireductone synthase activity
Molecular Functionmagnesium ion binding
Biological ProcessL-methionine salvage from methylthioadenosine
Biological ProcessL-methionine salvage from S-adenosylmethionine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Enolase-phosphatase E1
  • EC number
  • Alternative names
    • 2,3-diketo-5-methylthio-1-phosphopentane phosphatase

Gene names

    • Name
      ENOPH1
    • Synonyms
      UTR4
    • ORF names
      EC957_007771

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NRRL 2591
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mortierellomycotina > Mortierellomycetes > Mortierellales > Mortierellaceae > Mortierella

Accessions

  • Primary accession
    A0A9P6FBY3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-15Polar residues
Region1-70Disordered

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    400
  • Mass (Da)
    42,419
  • Last updated
    2023-09-13 v1
  • Checksum
    4B315AE16E262A89
MVLTRSRSNNQGNAAPALVPAPKKTAPATKRKASASAAPVPKVTKTDSTPDVATAKEVQPAPAEADPAPVETAPAPAAAVAVPADTPAPIPATAATTETLQPTKVPTPPPAIAAPEASTIPAPVEMPIVAAAEPVIASSEEPTLHHVIHPYDVVVTDIEGTTTPIVFVKENLFPYITSKLAEFLQRNWASEEMKSAVEALRVQAAKDVADGVADATPIAKESAEVTAEKVQQDVIASIGWQMKADRKIGALKAFQGYMWREGYTNGDLKGALYEDVIPAFDLWRAEGKKLYIYSSGSIDAQKLLFGFSEKGDLLHYFSGHYDTTIGLKVNAESYAKIAADIGLSPARILFLSDNIHEIVAAKKAGFQTVITDRPGNAPLTTEERDGNLVVKSFLEIPKSQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-15Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAAXW010000037
EMBL· GenBank· DDBJ
KAF9547824.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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